Metastatic Multiple Myeloma to the Skin
Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with relapsed lambda light chain MM who developed abrupt asymptomatic skin metastases....
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/7930123 |
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| author | Alex C. Holliday Mohammed I. Khan Sean E. Mazloom Rahul N. Chavan Douglas J. Grider |
| author_facet | Alex C. Holliday Mohammed I. Khan Sean E. Mazloom Rahul N. Chavan Douglas J. Grider |
| author_sort | Alex C. Holliday |
| collection | DOAJ |
| description | Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with relapsed lambda light chain MM who developed abrupt asymptomatic skin metastases. Biopsy revealed a dermis replete of atypical plasma cells, positive for CD138 and CD45. In situ hybridization confirmed lambda light chain restriction. Despite rescue antimyeloma therapy with the anti-CD38 drug daratumumab, he rapidly declined clinically and succumbed to the disease four weeks after presentation. A standard treatment approach for cutaneous MM does not currently exist; however, various techniques to detect cytogenetic abnormalities are emerging and will provide additional prognostic value and direct individualized therapy. |
| format | Article |
| id | doaj-art-b9618f24949748db9f9948a23cfb2b40 |
| institution | DOAJ |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-b9618f24949748db9f9948a23cfb2b402025-08-20T03:23:12ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712019-01-01201910.1155/2019/79301237930123Metastatic Multiple Myeloma to the SkinAlex C. Holliday0Mohammed I. Khan1Sean E. Mazloom2Rahul N. Chavan3Douglas J. Grider4Carilion Clinic and Virginia Tech Carilion School of Medicine, Department of Internal Medicine, Section of Dermatology, Roanoke, VA, USACarilion Clinic and Virginia Tech Carilion School of Medicine, Department of Internal Medicine, Section of Dermatology, Roanoke, VA, USACarilion Clinic and Virginia Tech Carilion School of Medicine, Department of Internal Medicine, Section of Dermatology, Roanoke, VA, USAAlabama College of Osteopathic Medicine, Dothan, AL, USACarilion Clinic and Virginia Tech Carilion School of Medicine, Department of Internal Medicine, Section of Dermatology, Roanoke, VA, USACutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with relapsed lambda light chain MM who developed abrupt asymptomatic skin metastases. Biopsy revealed a dermis replete of atypical plasma cells, positive for CD138 and CD45. In situ hybridization confirmed lambda light chain restriction. Despite rescue antimyeloma therapy with the anti-CD38 drug daratumumab, he rapidly declined clinically and succumbed to the disease four weeks after presentation. A standard treatment approach for cutaneous MM does not currently exist; however, various techniques to detect cytogenetic abnormalities are emerging and will provide additional prognostic value and direct individualized therapy.http://dx.doi.org/10.1155/2019/7930123 |
| spellingShingle | Alex C. Holliday Mohammed I. Khan Sean E. Mazloom Rahul N. Chavan Douglas J. Grider Metastatic Multiple Myeloma to the Skin Case Reports in Dermatological Medicine |
| title | Metastatic Multiple Myeloma to the Skin |
| title_full | Metastatic Multiple Myeloma to the Skin |
| title_fullStr | Metastatic Multiple Myeloma to the Skin |
| title_full_unstemmed | Metastatic Multiple Myeloma to the Skin |
| title_short | Metastatic Multiple Myeloma to the Skin |
| title_sort | metastatic multiple myeloma to the skin |
| url | http://dx.doi.org/10.1155/2019/7930123 |
| work_keys_str_mv | AT alexcholliday metastaticmultiplemyelomatotheskin AT mohammedikhan metastaticmultiplemyelomatotheskin AT seanemazloom metastaticmultiplemyelomatotheskin AT rahulnchavan metastaticmultiplemyelomatotheskin AT douglasjgrider metastaticmultiplemyelomatotheskin |