Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

IntroductionDuring rollout of mRNA-based COVID-19 vaccines, several jurisdictions extended the interval between the first and second doses to prioritize wider population access to limited vaccine supply. This study evaluated the effects of an extended dose interval on development of antibody and cel...

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Main Authors: Jessica I. Ahmed, Samantha J. Krosta, Mandy N. Reimer, Winnie Cheung, Christine Mesa, Carmen Lopez, Rayeil J. Chua, Farah Alsattari, Alyssia Robinson, Kathy Manguiat, Naima Jahan, Bernard Abrenica, Angela Harris, Karla Cachero, Rissa Fabia, Jonathan Walker, Myo Minn Oo, Derek Stein, Hezhao Ji, Ruey-Chyi Su, Paul J. McLaren, Lyle R. McKinnon, T Blake Ball, Heidi Wood, John Kim, Sandra A. Kiazyk, Catherine M. Card
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
COVID-19
mRNA vaccine
dose interval
antibody
breadth
neutralization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529134/full
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