Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings
Antimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming’s warning about the misuse of antibiotics leading to resistant microbes. With a dwindling arsenal of effective antibiotics, it is imperative to concentrate on alternative antimicrobial strat...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/14/1/57 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589352627077120 |
|---|---|
| author | Shyam Kumar Mishra Tanzina Akter Umme Laila Urmi George Enninful Manjulatha Sara Jiawei Shen Dittu Suresh Liangjun Zheng Elias Shiferaw Mekonen Binod Rayamajhee Francesco M. Labricciosa Massimo Sartelli Mark Willcox |
| author_facet | Shyam Kumar Mishra Tanzina Akter Umme Laila Urmi George Enninful Manjulatha Sara Jiawei Shen Dittu Suresh Liangjun Zheng Elias Shiferaw Mekonen Binod Rayamajhee Francesco M. Labricciosa Massimo Sartelli Mark Willcox |
| author_sort | Shyam Kumar Mishra |
| collection | DOAJ |
| description | Antimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming’s warning about the misuse of antibiotics leading to resistant microbes. With a dwindling arsenal of effective antibiotics, it is imperative to concentrate on alternative antimicrobial strategies. Previous studies have not comprehensively discussed the advantages and limitations of various strategies, including bacteriophage therapy, probiotics, immunotherapies, photodynamic therapy, essential oils, nanoparticles and antimicrobial peptides (AMPs) within a single review. This review addresses that gap by providing an overview of these various non-antibiotic antimicrobial strategies, highlighting their pros and cons, with a particular emphasis on antimicrobial peptides (AMPs). We explore the mechanism of action of AMPs against bacteria, viruses, fungi and parasites. While these peptides hold significant promise, their application in mainstream drug development is hindered by challenges such as low bioavailability and potential toxicity. However, advancements in peptide engineering and chemical modifications offer solutions to enhance their clinical utility. Additionally, this review presents updates on strategies aimed at improving the cost, stability and selective toxicity of AMPs through the development of peptidomimetics. These molecules have demonstrated effective activity against a broad range of pathogens, making them valuable candidates for integration into surface coatings to prevent device-associated infections. Furthermore, we discuss various approaches for attaching and functionalising these peptides on surfaces. Finally, we recommend comprehensive in vivo studies to evaluate the efficacy of AMPs and their mimetics, investigate their synergistic combinations with other molecules and assess their potential as coatings for medical devices. |
| format | Article |
| id | doaj-art-b95a92aba8154b4f8a7554f3d7df3eba |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-b95a92aba8154b4f8a7554f3d7df3eba2025-01-24T13:18:46ZengMDPI AGAntibiotics2079-63822025-01-011415710.3390/antibiotics14010057Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their CoatingsShyam Kumar Mishra0Tanzina Akter1Umme Laila Urmi2George Enninful3Manjulatha Sara4Jiawei Shen5Dittu Suresh6Liangjun Zheng7Elias Shiferaw Mekonen8Binod Rayamajhee9Francesco M. Labricciosa10Massimo Sartelli11Mark Willcox12School of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Chemistry, Faculty of Science, University of New South Wales, Sydney, NSW 2052, AustraliaDepartment of Animal Science and Technology, University of Northwest A&F, Yangling 712100, ChinaSchool of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaGlobal Alliance for Infections in Surgery, 62100 Macerata, ItalyDepartment of Surgery, Macerata Hospital, 62100 Macerata, ItalySchool of Optometry and Vision Science, Faculty of Health and Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaAntimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming’s warning about the misuse of antibiotics leading to resistant microbes. With a dwindling arsenal of effective antibiotics, it is imperative to concentrate on alternative antimicrobial strategies. Previous studies have not comprehensively discussed the advantages and limitations of various strategies, including bacteriophage therapy, probiotics, immunotherapies, photodynamic therapy, essential oils, nanoparticles and antimicrobial peptides (AMPs) within a single review. This review addresses that gap by providing an overview of these various non-antibiotic antimicrobial strategies, highlighting their pros and cons, with a particular emphasis on antimicrobial peptides (AMPs). We explore the mechanism of action of AMPs against bacteria, viruses, fungi and parasites. While these peptides hold significant promise, their application in mainstream drug development is hindered by challenges such as low bioavailability and potential toxicity. However, advancements in peptide engineering and chemical modifications offer solutions to enhance their clinical utility. Additionally, this review presents updates on strategies aimed at improving the cost, stability and selective toxicity of AMPs through the development of peptidomimetics. These molecules have demonstrated effective activity against a broad range of pathogens, making them valuable candidates for integration into surface coatings to prevent device-associated infections. Furthermore, we discuss various approaches for attaching and functionalising these peptides on surfaces. Finally, we recommend comprehensive in vivo studies to evaluate the efficacy of AMPs and their mimetics, investigate their synergistic combinations with other molecules and assess their potential as coatings for medical devices.https://www.mdpi.com/2079-6382/14/1/57antimicrobial coatingantimicrobial peptideantimicrobial resistancepeptide engineeringpeptidomimetics |
| spellingShingle | Shyam Kumar Mishra Tanzina Akter Umme Laila Urmi George Enninful Manjulatha Sara Jiawei Shen Dittu Suresh Liangjun Zheng Elias Shiferaw Mekonen Binod Rayamajhee Francesco M. Labricciosa Massimo Sartelli Mark Willcox Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings Antibiotics antimicrobial coating antimicrobial peptide antimicrobial resistance peptide engineering peptidomimetics |
| title | Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings |
| title_full | Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings |
| title_fullStr | Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings |
| title_full_unstemmed | Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings |
| title_short | Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings |
| title_sort | harnessing non antibiotic strategies to counter multidrug resistant clinical pathogens with special reference to antimicrobial peptides and their coatings |
| topic | antimicrobial coating antimicrobial peptide antimicrobial resistance peptide engineering peptidomimetics |
| url | https://www.mdpi.com/2079-6382/14/1/57 |
| work_keys_str_mv | AT shyamkumarmishra harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT tanzinaakter harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT ummelailaurmi harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT georgeenninful harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT manjulathasara harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT jiaweishen harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT dittusuresh harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT liangjunzheng harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT eliasshiferawmekonen harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT binodrayamajhee harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT francescomlabricciosa harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT massimosartelli harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings AT markwillcox harnessingnonantibioticstrategiestocountermultidrugresistantclinicalpathogenswithspecialreferencetoantimicrobialpeptidesandtheircoatings |