Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review.
<h4>Background</h4>Acute febrile illness (AFI), a common reason for people seeking medical care globally, represents a spectrum of infectious disease etiologies with important variations geographically and by population. There is no standardized approach to conducting AFI etiologic inves...
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Public Library of Science (PLoS)
2019-11-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007792&type=printable |
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| author | Chulwoo Rhee Grishma A Kharod Nicolas Schaad Nathan W Furukawa Neil M Vora David D Blaney John A Crump Kevin R Clarke |
| author_facet | Chulwoo Rhee Grishma A Kharod Nicolas Schaad Nathan W Furukawa Neil M Vora David D Blaney John A Crump Kevin R Clarke |
| author_sort | Chulwoo Rhee |
| collection | DOAJ |
| description | <h4>Background</h4>Acute febrile illness (AFI), a common reason for people seeking medical care globally, represents a spectrum of infectious disease etiologies with important variations geographically and by population. There is no standardized approach to conducting AFI etiologic investigations, limiting interpretation of data in a global context. We conducted a scoping review to characterize current AFI research methodologies, identify global research gaps, and provide methodological research standardization recommendations.<h4>Methodology/findings</h4>Using pre-defined terms, we searched Medline, Embase, and Global Health, for publications from January 1, 2005-December 31, 2017. Publications cited in previously published systematic reviews and an online study repository of non-malarial febrile illness etiologies were also included. We screened abstracts for publications reporting on human infectious disease, aimed at determining AFI etiology using laboratory diagnostics. One-hundred ninety publications underwent full-text review, using a standardized tool to collect data on study characteristics, methodology, and laboratory diagnostics. AFI case definitions between publications varied: use of self-reported fever as part of case definitions (28%, 53/190), fever cut-off value (38·0°C most commonly used: 45%, 85/190), and fever measurement site (axillary most commonly used: 19%, 36/190). Eighty-nine publications (47%) did not include exclusion criteria, and inclusion criteria in 13% (24/190) of publications did not include age group. No publications included study settings in Southern Africa, Micronesia & Polynesia, or Central Asia. We summarized standardized reporting practices, specific to AFI etiologic investigations that would increase inter-study comparability.<h4>Conclusions</h4>Wider implementation of standardized AFI reporting methods, with multi-pathogen disease detection, could improve comparability of study findings, knowledge of the range of AFI etiologies, and their contributions to the global AFI burden. These steps can guide resource allocation, strengthen outbreak detection and response, target prevention efforts, and improve clinical care, especially in resource-limited settings where disease control often relies on empiric treatment. PROSPERO: CRD42016035666. |
| format | Article |
| id | doaj-art-b95447fa0bbf437fb33eb4779286fab9 |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-b95447fa0bbf437fb33eb4779286fab92025-02-05T05:33:34ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352019-11-011311e000779210.1371/journal.pntd.0007792Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review.Chulwoo RheeGrishma A KharodNicolas SchaadNathan W FurukawaNeil M VoraDavid D BlaneyJohn A CrumpKevin R Clarke<h4>Background</h4>Acute febrile illness (AFI), a common reason for people seeking medical care globally, represents a spectrum of infectious disease etiologies with important variations geographically and by population. There is no standardized approach to conducting AFI etiologic investigations, limiting interpretation of data in a global context. We conducted a scoping review to characterize current AFI research methodologies, identify global research gaps, and provide methodological research standardization recommendations.<h4>Methodology/findings</h4>Using pre-defined terms, we searched Medline, Embase, and Global Health, for publications from January 1, 2005-December 31, 2017. Publications cited in previously published systematic reviews and an online study repository of non-malarial febrile illness etiologies were also included. We screened abstracts for publications reporting on human infectious disease, aimed at determining AFI etiology using laboratory diagnostics. One-hundred ninety publications underwent full-text review, using a standardized tool to collect data on study characteristics, methodology, and laboratory diagnostics. AFI case definitions between publications varied: use of self-reported fever as part of case definitions (28%, 53/190), fever cut-off value (38·0°C most commonly used: 45%, 85/190), and fever measurement site (axillary most commonly used: 19%, 36/190). Eighty-nine publications (47%) did not include exclusion criteria, and inclusion criteria in 13% (24/190) of publications did not include age group. No publications included study settings in Southern Africa, Micronesia & Polynesia, or Central Asia. We summarized standardized reporting practices, specific to AFI etiologic investigations that would increase inter-study comparability.<h4>Conclusions</h4>Wider implementation of standardized AFI reporting methods, with multi-pathogen disease detection, could improve comparability of study findings, knowledge of the range of AFI etiologies, and their contributions to the global AFI burden. These steps can guide resource allocation, strengthen outbreak detection and response, target prevention efforts, and improve clinical care, especially in resource-limited settings where disease control often relies on empiric treatment. PROSPERO: CRD42016035666.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007792&type=printable |
| spellingShingle | Chulwoo Rhee Grishma A Kharod Nicolas Schaad Nathan W Furukawa Neil M Vora David D Blaney John A Crump Kevin R Clarke Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review. PLoS Neglected Tropical Diseases |
| title | Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review. |
| title_full | Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review. |
| title_fullStr | Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review. |
| title_full_unstemmed | Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review. |
| title_short | Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review. |
| title_sort | global knowledge gaps in acute febrile illness etiologic investigations a scoping review |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007792&type=printable |
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