X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL

X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL

Abstract Acute lymphoblastic leukemia (ALL) represents the most frequent malignancy in children, and relapse/refractory (r/r) disease is difficult to treat, both in children and adults. In search for novel treatment options against r/r ALL, we studied inhibitor of apoptosis proteins (IAP) and Smac m...

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Main Authors: Michela Carlet, Karin Schmelz, Jenny Vergalli, Tobias Herold, Daniela Senft, Vindi Jurinovic, Thomas Hoffmann, Jutta Proba, Nina Weichert, Christian Junghanß, Mareike Roth, Georg Eschenburg, Malwine Barz, Günter Henze, Cornelia Eckert, Angelika Eggert, Johannes Zuber, Patrick Hundsdoerfer, Irmela Jeremias
Format: Article
Language:English
Published: Springer Nature 2022-11-01
Series:EMBO Molecular Medicine
Subjects:
PDX
relapsed/refractory acute lymphoblastic leukemia
smac mimetics
therapeutic target
XIAP
Online Access:https://doi.org/10.15252/emmm.202114557
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