Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's disease
Abstract Introduction Animal models of Alzheimer's disease show that exercise may modify β‐amyloid (Aβ) deposition. We examined the effect of a 16‐week exercise intervention on cortical Aβ in patients with mild‐to‐moderate Alzheimer's disease. Methods Thirty‐six patients with Alzheimer...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2019.04.006 |
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| author | Kristian S. Frederiksen Karine Madsen Birgitte B. Andersen Nina Beyer Ellen Garde Peter Høgh Gunhild Waldemar Steen G. Hasselbalch Ian Law |
| author_facet | Kristian S. Frederiksen Karine Madsen Birgitte B. Andersen Nina Beyer Ellen Garde Peter Høgh Gunhild Waldemar Steen G. Hasselbalch Ian Law |
| author_sort | Kristian S. Frederiksen |
| collection | DOAJ |
| description | Abstract Introduction Animal models of Alzheimer's disease show that exercise may modify β‐amyloid (Aβ) deposition. We examined the effect of a 16‐week exercise intervention on cortical Aβ in patients with mild‐to‐moderate Alzheimer's disease. Methods Thirty‐six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon‐Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs). Results The intervention showed no effect on follow‐up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini–Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. Discussion The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions. |
| format | Article |
| id | doaj-art-b951305d0b1f447dafdf94400d3bb6e1 |
| institution | OA Journals |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-b951305d0b1f447dafdf94400d3bb6e12025-08-20T02:09:55ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-015120821510.1016/j.trci.2019.04.006Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's diseaseKristian S. Frederiksen0Karine Madsen1Birgitte B. Andersen2Nina Beyer3Ellen Garde4Peter Høgh5Gunhild Waldemar6Steen G. Hasselbalch7Ian Law8Danish Dementia Research Centre, Department of Neurology, RigshospitaletUniversity of CopenhagenCopenhagenDenmarkNeurobiology Research UnitCopenhagenDenmarkDanish Dementia Research Centre, Department of Neurology, RigshospitaletUniversity of CopenhagenCopenhagenDenmarkMusculoskeletal Rehabilitation Research Unit and Institute of Sports Medicine, Bispebjerg Hospital, University of CopenhagenCopenhagenDenmarkDanish Research Centre for Magnetic ResonanceCopenhagen University Hospital HvidovreHvidovreDenmarkZealand University HospitalDepartment of NeurologyRoskildeDenmarkDanish Dementia Research Centre, Department of Neurology, RigshospitaletUniversity of CopenhagenCopenhagenDenmarkDanish Dementia Research Centre, Department of Neurology, RigshospitaletUniversity of CopenhagenCopenhagenDenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET, RigshospitaletUniversity of CopenhagenCopenhagenDenmarkAbstract Introduction Animal models of Alzheimer's disease show that exercise may modify β‐amyloid (Aβ) deposition. We examined the effect of a 16‐week exercise intervention on cortical Aβ in patients with mild‐to‐moderate Alzheimer's disease. Methods Thirty‐six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon‐Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs). Results The intervention showed no effect on follow‐up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini–Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. Discussion The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.https://doi.org/10.1016/j.trci.2019.04.00611C‐PiB‐PETAerobic exerciseAlzheimer's diseaseβ‐amyloidExerciseDementia |
| spellingShingle | Kristian S. Frederiksen Karine Madsen Birgitte B. Andersen Nina Beyer Ellen Garde Peter Høgh Gunhild Waldemar Steen G. Hasselbalch Ian Law Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's disease Alzheimer’s & Dementia: Translational Research & Clinical Interventions 11C‐PiB‐PET Aerobic exercise Alzheimer's disease β‐amyloid Exercise Dementia |
| title | Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's disease |
| title_full | Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's disease |
| title_fullStr | Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's disease |
| title_full_unstemmed | Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's disease |
| title_short | Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's disease |
| title_sort | moderate to high intensity exercise does not modify cortical β amyloid in alzheimer s disease |
| topic | 11C‐PiB‐PET Aerobic exercise Alzheimer's disease β‐amyloid Exercise Dementia |
| url | https://doi.org/10.1016/j.trci.2019.04.006 |
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