Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study
Purpose. The main purpose of this study was to investigate the dynamics of pentraxin 3 (PTX3) compared with procalcitonin (PCT) and C-reactive protein (CRP) in patients with suspicion of ventilator-associated pneumonia (VAP). Materials and Methods. We designed a nested case-control study. This study...
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2018/4074169 |
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| author | Huseyin Bilgin Murat Haliloglu Ali Yaman Pinar Ay Beliz Bilgili Mustafa Kemal Arslantas Filiz Ture Ozdemir Goncagul Haklar Ismail Cinel Lutfiye Mulazimoglu |
| author_facet | Huseyin Bilgin Murat Haliloglu Ali Yaman Pinar Ay Beliz Bilgili Mustafa Kemal Arslantas Filiz Ture Ozdemir Goncagul Haklar Ismail Cinel Lutfiye Mulazimoglu |
| author_sort | Huseyin Bilgin |
| collection | DOAJ |
| description | Purpose. The main purpose of this study was to investigate the dynamics of pentraxin 3 (PTX3) compared with procalcitonin (PCT) and C-reactive protein (CRP) in patients with suspicion of ventilator-associated pneumonia (VAP). Materials and Methods. We designed a nested case-control study. This study was performed in the Surgical Intensive Care Unit of a tertiary care academic university and teaching hospital. Ninety-one adults who were mechanically ventilated for >48 hours were enrolled in the study. VAP diagnosis was established among 28 patients following the 2005 ATS/IDSA guidelines. Results. The median PTX3 plasma level was 2.66 ng/mL in VAP adults compared to 0.25 ng/mL in non-VAP adults (p<0.05). Procalcitonin and CRP levels did not significantly differ. Pentraxin 3, with a 2.56 ng/mL breakpoint, had 85% sensitivity, 86% specificity, 75% positive predictive value, and 92.9% negative predictive value for VAP diagnosis (AUC = 0.78). Conclusions. With the suspicion of VAP, a pentraxin 3 plasma breakpoint of 2.56 ng/mL could contribute to the decision of whether to start antibiotics. |
| format | Article |
| id | doaj-art-b95114c9361349e285b034a6a7485db5 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-b95114c9361349e285b034a6a7485db52025-02-03T05:47:18ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932018-01-01201810.1155/2018/40741694074169Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control StudyHuseyin Bilgin0Murat Haliloglu1Ali Yaman2Pinar Ay3Beliz Bilgili4Mustafa Kemal Arslantas5Filiz Ture Ozdemir6Goncagul Haklar7Ismail Cinel8Lutfiye Mulazimoglu9Infectious Diseases and Clinical Microbiology, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Anesthesiology and Intensive Care, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Biochemistry, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Public Health, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Anesthesiology and Intensive Care, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Anesthesiology and Intensive Care, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Immunology, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Biochemistry, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Anesthesiology and Intensive Care, Marmara University School of Medicine, Istanbul, TurkeyInfectious Diseases and Clinical Microbiology, Marmara University School of Medicine, Istanbul, TurkeyPurpose. The main purpose of this study was to investigate the dynamics of pentraxin 3 (PTX3) compared with procalcitonin (PCT) and C-reactive protein (CRP) in patients with suspicion of ventilator-associated pneumonia (VAP). Materials and Methods. We designed a nested case-control study. This study was performed in the Surgical Intensive Care Unit of a tertiary care academic university and teaching hospital. Ninety-one adults who were mechanically ventilated for >48 hours were enrolled in the study. VAP diagnosis was established among 28 patients following the 2005 ATS/IDSA guidelines. Results. The median PTX3 plasma level was 2.66 ng/mL in VAP adults compared to 0.25 ng/mL in non-VAP adults (p<0.05). Procalcitonin and CRP levels did not significantly differ. Pentraxin 3, with a 2.56 ng/mL breakpoint, had 85% sensitivity, 86% specificity, 75% positive predictive value, and 92.9% negative predictive value for VAP diagnosis (AUC = 0.78). Conclusions. With the suspicion of VAP, a pentraxin 3 plasma breakpoint of 2.56 ng/mL could contribute to the decision of whether to start antibiotics.http://dx.doi.org/10.1155/2018/4074169 |
| spellingShingle | Huseyin Bilgin Murat Haliloglu Ali Yaman Pinar Ay Beliz Bilgili Mustafa Kemal Arslantas Filiz Ture Ozdemir Goncagul Haklar Ismail Cinel Lutfiye Mulazimoglu Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study |
| title_full | Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study |
| title_fullStr | Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study |
| title_full_unstemmed | Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study |
| title_short | Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study |
| title_sort | sequential measurements of pentraxin 3 serum levels in patients with ventilator associated pneumonia a nested case control study |
| url | http://dx.doi.org/10.1155/2018/4074169 |
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