Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function
Abstract Type 2 diabetes mellitus (T2DM) is closely associated with an increased risk and adverse event of acute coronary syndrome (ACS). The present study aims to investigate the association between differential urinary metabolites and major adverse cardiovascular events (MACEs) in patients with AC...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-96010-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850146317311934464 |
|---|---|
| author | Mingyu Duan Zhihan Zhang Ruhua He Yameng Zhang Xueying Zhang Miradil Dilshat Jun He |
| author_facet | Mingyu Duan Zhihan Zhang Ruhua He Yameng Zhang Xueying Zhang Miradil Dilshat Jun He |
| author_sort | Mingyu Duan |
| collection | DOAJ |
| description | Abstract Type 2 diabetes mellitus (T2DM) is closely associated with an increased risk and adverse event of acute coronary syndrome (ACS). The present study aims to investigate the association between differential urinary metabolites and major adverse cardiovascular events (MACEs) in patients with ACS co-morbid T2DM with preserved renal function, and to explore the potential value of the metabolites as prognostic biomarkers in this population. Ultra-high performance liquid chromatography-mass spectrometry (UHPLC/MS) was used to analyze urine samples from ACS co-morbid T2DM. Spearman’s correlation was used to examine the association between differential metabolites and serum fasting blood glucose (FBG), glycated hemoglobin (HbA1c), Syntax score I, and MACE. The Cox proportional hazards models and Kaplan–Meier survival curves were used to identify MACE risk factors. A total of 101 differential urinary metabolites were identified, of which seven showed a correlation with FBG, HbA1c, Syntax score I and MACE. In particular, myo-inositol and (E)-Monocrotophos emerged as significant indicators of poor prognosis in ACS co-morbid with T2DM. Urinary metabolomic alteration is closely associated with clinical manifestation of ACS co-morbid T2DM. Urinary myo-inositol and (E)-Monocrotophos may be considered as prognostic biomarkers of ACS co-morbid T2DM. |
| format | Article |
| id | doaj-art-b94eb29d2a5a4e8bada0b1bb3af41097 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b94eb29d2a5a4e8bada0b1bb3af410972025-08-20T02:27:53ZengNature PortfolioScientific Reports2045-23222025-04-0115111410.1038/s41598-025-96010-wUrinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal functionMingyu Duan0Zhihan Zhang1Ruhua He2Yameng Zhang3Xueying Zhang4Miradil Dilshat5Jun He6Department of Ultrasound of Jiangbei Campus, The First Affiliated Hospital of Army Medical University (The 958th Hospital of Chinese People‘s Liberation Army)Department of Cardiology, Hanzhong Central HospitalDepartment of Cardiology, General Hospital of Ningxia Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Henan University of Science and TechnologyNingxia Medical UniversityNingxia Medical UniversityDepartment of Cardiology, General Hospital of Ningxia Medical UniversityAbstract Type 2 diabetes mellitus (T2DM) is closely associated with an increased risk and adverse event of acute coronary syndrome (ACS). The present study aims to investigate the association between differential urinary metabolites and major adverse cardiovascular events (MACEs) in patients with ACS co-morbid T2DM with preserved renal function, and to explore the potential value of the metabolites as prognostic biomarkers in this population. Ultra-high performance liquid chromatography-mass spectrometry (UHPLC/MS) was used to analyze urine samples from ACS co-morbid T2DM. Spearman’s correlation was used to examine the association between differential metabolites and serum fasting blood glucose (FBG), glycated hemoglobin (HbA1c), Syntax score I, and MACE. The Cox proportional hazards models and Kaplan–Meier survival curves were used to identify MACE risk factors. A total of 101 differential urinary metabolites were identified, of which seven showed a correlation with FBG, HbA1c, Syntax score I and MACE. In particular, myo-inositol and (E)-Monocrotophos emerged as significant indicators of poor prognosis in ACS co-morbid with T2DM. Urinary metabolomic alteration is closely associated with clinical manifestation of ACS co-morbid T2DM. Urinary myo-inositol and (E)-Monocrotophos may be considered as prognostic biomarkers of ACS co-morbid T2DM.https://doi.org/10.1038/s41598-025-96010-wAcute coronary syndromeType 2 diabetes mellitusMetabolomicsMajor adverse cardiovascular eventsPrognosis |
| spellingShingle | Mingyu Duan Zhihan Zhang Ruhua He Yameng Zhang Xueying Zhang Miradil Dilshat Jun He Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function Scientific Reports Acute coronary syndrome Type 2 diabetes mellitus Metabolomics Major adverse cardiovascular events Prognosis |
| title | Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function |
| title_full | Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function |
| title_fullStr | Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function |
| title_full_unstemmed | Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function |
| title_short | Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function |
| title_sort | urinary metabolomics reveals myo inositol and e monocrotophos associate with prognosis in acs comorbid with t2dm and preserved renal function |
| topic | Acute coronary syndrome Type 2 diabetes mellitus Metabolomics Major adverse cardiovascular events Prognosis |
| url | https://doi.org/10.1038/s41598-025-96010-w |
| work_keys_str_mv | AT mingyuduan urinarymetabolomicsrevealsmyoinositolandemonocrotophosassociatewithprognosisinacscomorbidwitht2dmandpreservedrenalfunction AT zhihanzhang urinarymetabolomicsrevealsmyoinositolandemonocrotophosassociatewithprognosisinacscomorbidwitht2dmandpreservedrenalfunction AT ruhuahe urinarymetabolomicsrevealsmyoinositolandemonocrotophosassociatewithprognosisinacscomorbidwitht2dmandpreservedrenalfunction AT yamengzhang urinarymetabolomicsrevealsmyoinositolandemonocrotophosassociatewithprognosisinacscomorbidwitht2dmandpreservedrenalfunction AT xueyingzhang urinarymetabolomicsrevealsmyoinositolandemonocrotophosassociatewithprognosisinacscomorbidwitht2dmandpreservedrenalfunction AT miradildilshat urinarymetabolomicsrevealsmyoinositolandemonocrotophosassociatewithprognosisinacscomorbidwitht2dmandpreservedrenalfunction AT junhe urinarymetabolomicsrevealsmyoinositolandemonocrotophosassociatewithprognosisinacscomorbidwitht2dmandpreservedrenalfunction |