Ordered assemblies of peptide nanoparticles with only positive charge
Abstract Surface charge patchiness of different charge types can influence the solution behaviours of colloidal particles and globular proteins. Herein, coiled-coil ‘bundlemer’ nanoparticles that display only a single type of surface charge (SC) are computationally designed to compare their solution...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54340-9 |
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| author | Yi Shi Tianren Zhang Rui Guo Zihan Zhang Amanda L. McCahill Yao Tang Sabrina E. Liskey Dai-Bei Yang Christopher J. Kloxin Jeffery G. Saven Darrin J. Pochan |
| author_facet | Yi Shi Tianren Zhang Rui Guo Zihan Zhang Amanda L. McCahill Yao Tang Sabrina E. Liskey Dai-Bei Yang Christopher J. Kloxin Jeffery G. Saven Darrin J. Pochan |
| author_sort | Yi Shi |
| collection | DOAJ |
| description | Abstract Surface charge patchiness of different charge types can influence the solution behaviours of colloidal particles and globular proteins. Herein, coiled-coil ‘bundlemer’ nanoparticles that display only a single type of surface charge (SC) are computationally designed to compare their solution behaviours to mixed charge-type (MC) counterparts with both positively and negatively charged side chains. Nematic and columnar liquid crystal phases are discovered in low concentrations of SC particles, indicative of particle end-to-end stacking into columns combined with lateral electrostatic repulsion between columns, while MC particles with the same net charge and particle shape produced only amorphous, soluble aggregates. Similarly, porous lattices are formed in mixtures of SC/MC particles of opposite charges while MC/MC mixtures of opposite charges produce only amorphous aggregates. The lattice structure is inferred with a machine learning optimization approach. The differences between SC and MC particle behaviours directly show the importance of surface electrostatic patchiness. |
| format | Article |
| id | doaj-art-b94d0f201150413c91aa62fbc09c883f |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-b94d0f201150413c91aa62fbc09c883f2025-08-20T02:33:06ZengNature PortfolioNature Communications2041-17232024-11-0115111110.1038/s41467-024-54340-9Ordered assemblies of peptide nanoparticles with only positive chargeYi Shi0Tianren Zhang1Rui Guo2Zihan Zhang3Amanda L. McCahill4Yao Tang5Sabrina E. Liskey6Dai-Bei Yang7Christopher J. Kloxin8Jeffery G. Saven9Darrin J. Pochan10Department of Materials Science and Engineering, University of DelawareDepartment of Materials Science and Engineering, University of DelawareDepartment of Chemistry, University of PennsylvaniaDepartment of Materials Science and Engineering, University of DelawareDepartment of Materials Science and Engineering, University of DelawareDepartment of Materials Science and Engineering, University of DelawareDepartment of Materials Science and Engineering, University of DelawareDepartment of Chemistry, University of PennsylvaniaDepartment of Materials Science and Engineering, University of DelawareDepartment of Chemistry, University of PennsylvaniaDepartment of Materials Science and Engineering, University of DelawareAbstract Surface charge patchiness of different charge types can influence the solution behaviours of colloidal particles and globular proteins. Herein, coiled-coil ‘bundlemer’ nanoparticles that display only a single type of surface charge (SC) are computationally designed to compare their solution behaviours to mixed charge-type (MC) counterparts with both positively and negatively charged side chains. Nematic and columnar liquid crystal phases are discovered in low concentrations of SC particles, indicative of particle end-to-end stacking into columns combined with lateral electrostatic repulsion between columns, while MC particles with the same net charge and particle shape produced only amorphous, soluble aggregates. Similarly, porous lattices are formed in mixtures of SC/MC particles of opposite charges while MC/MC mixtures of opposite charges produce only amorphous aggregates. The lattice structure is inferred with a machine learning optimization approach. The differences between SC and MC particle behaviours directly show the importance of surface electrostatic patchiness.https://doi.org/10.1038/s41467-024-54340-9 |
| spellingShingle | Yi Shi Tianren Zhang Rui Guo Zihan Zhang Amanda L. McCahill Yao Tang Sabrina E. Liskey Dai-Bei Yang Christopher J. Kloxin Jeffery G. Saven Darrin J. Pochan Ordered assemblies of peptide nanoparticles with only positive charge Nature Communications |
| title | Ordered assemblies of peptide nanoparticles with only positive charge |
| title_full | Ordered assemblies of peptide nanoparticles with only positive charge |
| title_fullStr | Ordered assemblies of peptide nanoparticles with only positive charge |
| title_full_unstemmed | Ordered assemblies of peptide nanoparticles with only positive charge |
| title_short | Ordered assemblies of peptide nanoparticles with only positive charge |
| title_sort | ordered assemblies of peptide nanoparticles with only positive charge |
| url | https://doi.org/10.1038/s41467-024-54340-9 |
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