A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advances
IgG4-related pancreatitis (IRP) is a form of chronic pancreatitis characterized by the infiltration of IgG4-positive plasma cells, representing a pancreatic manifestation of IgG4-related disease (IgG4-RD). In recent years, with the growing understanding of IgG4-RD, the incidence of IRP has shown an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590902/full |
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| author | Siqin Wu Xiaowen Qin Zhenjing Jin Lanlan Yang |
| author_facet | Siqin Wu Xiaowen Qin Zhenjing Jin Lanlan Yang |
| author_sort | Siqin Wu |
| collection | DOAJ |
| description | IgG4-related pancreatitis (IRP) is a form of chronic pancreatitis characterized by the infiltration of IgG4-positive plasma cells, representing a pancreatic manifestation of IgG4-related disease (IgG4-RD). In recent years, with the growing understanding of IgG4-RD, the incidence of IRP has shown an increasing trend. This article provides a comprehensive review of the latest advancements in the epidemiology, etiology, pathogenesis, clinical manifestations, diagnosis, differential diagnosis, and treatment of IRP. |
| format | Article |
| id | doaj-art-b948e558667e46a7ade4586a25f3f1ee |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b948e558667e46a7ade4586a25f3f1ee2025-08-20T02:39:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15909021590902A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advancesSiqin WuXiaowen QinZhenjing JinLanlan YangIgG4-related pancreatitis (IRP) is a form of chronic pancreatitis characterized by the infiltration of IgG4-positive plasma cells, representing a pancreatic manifestation of IgG4-related disease (IgG4-RD). In recent years, with the growing understanding of IgG4-RD, the incidence of IRP has shown an increasing trend. This article provides a comprehensive review of the latest advancements in the epidemiology, etiology, pathogenesis, clinical manifestations, diagnosis, differential diagnosis, and treatment of IRP.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590902/fullIgG4-related pancreatitisIgG4-related diseasediagnosistreatmentpathological mechanism |
| spellingShingle | Siqin Wu Xiaowen Qin Zhenjing Jin Lanlan Yang A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advances Frontiers in Immunology IgG4-related pancreatitis IgG4-related disease diagnosis treatment pathological mechanism |
| title | A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advances |
| title_full | A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advances |
| title_fullStr | A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advances |
| title_full_unstemmed | A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advances |
| title_short | A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advances |
| title_sort | comprehensive review of igg4 related pancreatitis pathogenesis diagnosis and therapeutic advances |
| topic | IgG4-related pancreatitis IgG4-related disease diagnosis treatment pathological mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590902/full |
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