A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds
Abstract Traditionally, raw cow milk has been employed to treat acid and thermal burns due to its antibacterial, antibiotic, and antifungal properties. It also aids in preventing scarring and alleviating burn-related skin discomfort. This study focuses on evaluating a nanoemulsion cream made from ca...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2025-01-01
|
| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100320&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592526510391296 |
|---|---|
| author | Shivani Shrivastava Saumya Das Chanchal Sharma Archna Singh Sanjita Das Manas Kumar Das Pankaj Kumar Tyagi Navneet Khurana |
| author_facet | Shivani Shrivastava Saumya Das Chanchal Sharma Archna Singh Sanjita Das Manas Kumar Das Pankaj Kumar Tyagi Navneet Khurana |
| author_sort | Shivani Shrivastava |
| collection | DOAJ |
| description | Abstract Traditionally, raw cow milk has been employed to treat acid and thermal burns due to its antibacterial, antibiotic, and antifungal properties. It also aids in preventing scarring and alleviating burn-related skin discomfort. This study focuses on evaluating a nanoemulsion cream made from casein extracted from raw cow milk for managing acid and thermal burns. Casein was isolated and used to create 2%, 5%, and 10% w/w nanoemulsion creams. Wistar albino rats were used to induce acid and thermal burns, and the healing progress was monitored by measuring wound contraction and epithelialization period. The results demonstrated significant wound healing effects of the casein creams (p<0.001) in acid burns, with the 10% w/w cream showing the highest epithelization rate in thermal burns. Raw milk also exhibited notable healing properties in acid burns. However, its effectiveness was relatively lower in thermal burns. This study suggests that raw milk and its casein-derived creams could be utilized as first-aid treatments for acid burns, though they may be less effective for thermal burns. |
| format | Article |
| id | doaj-art-b93f5eb1c51a46b4b0ac72de7e218c58 |
| institution | Kabale University |
| issn | 2175-9790 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj-art-b93f5eb1c51a46b4b0ac72de7e218c582025-01-21T07:42:00ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902025-01-016110.1590/s2175-97902025e24233A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn woundsShivani ShrivastavaSaumya Dashttps://orcid.org/0000-0002-8531-9963Chanchal SharmaArchna Singhhttps://orcid.org/0009-0003-4109-9158Sanjita Dashttps://orcid.org/0000-0002-9863-9341Manas Kumar Dashttps://orcid.org/0000-0002-9785-8905Pankaj Kumar Tyagihttps://orcid.org/0000-0002-7003-0489Navneet Khuranahttps://orcid.org/0000-0001-9899-4856Abstract Traditionally, raw cow milk has been employed to treat acid and thermal burns due to its antibacterial, antibiotic, and antifungal properties. It also aids in preventing scarring and alleviating burn-related skin discomfort. This study focuses on evaluating a nanoemulsion cream made from casein extracted from raw cow milk for managing acid and thermal burns. Casein was isolated and used to create 2%, 5%, and 10% w/w nanoemulsion creams. Wistar albino rats were used to induce acid and thermal burns, and the healing progress was monitored by measuring wound contraction and epithelialization period. The results demonstrated significant wound healing effects of the casein creams (p<0.001) in acid burns, with the 10% w/w cream showing the highest epithelization rate in thermal burns. Raw milk also exhibited notable healing properties in acid burns. However, its effectiveness was relatively lower in thermal burns. This study suggests that raw milk and its casein-derived creams could be utilized as first-aid treatments for acid burns, though they may be less effective for thermal burns.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100320&lng=en&tlng=enAcid burnCaseinCreamHydroxyprolineNanoemulsionRaw milkThermal wound |
| spellingShingle | Shivani Shrivastava Saumya Das Chanchal Sharma Archna Singh Sanjita Das Manas Kumar Das Pankaj Kumar Tyagi Navneet Khurana A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds Brazilian Journal of Pharmaceutical Sciences Acid burn Casein Cream Hydroxyproline Nanoemulsion Raw milk Thermal wound |
| title | A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds |
| title_full | A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds |
| title_fullStr | A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds |
| title_full_unstemmed | A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds |
| title_short | A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds |
| title_sort | novel nano emulsion cream of casein isolated from raw milk for thermal and acid burn wounds |
| topic | Acid burn Casein Cream Hydroxyproline Nanoemulsion Raw milk Thermal wound |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100320&lng=en&tlng=en |
| work_keys_str_mv | AT shivanishrivastava anovelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT saumyadas anovelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT chanchalsharma anovelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT archnasingh anovelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT sanjitadas anovelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT manaskumardas anovelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT pankajkumartyagi anovelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT navneetkhurana anovelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT shivanishrivastava novelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT saumyadas novelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT chanchalsharma novelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT archnasingh novelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT sanjitadas novelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT manaskumardas novelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT pankajkumartyagi novelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds AT navneetkhurana novelnanoemulsioncreamofcaseinisolatedfromrawmilkforthermalandacidburnwounds |