Synergies from a distance: Inspirations from the struggles of Dr James M Krueger
In this article for Dr Krueger's Festschrift, I trace how his early career influenced many aspects in the fields of sleep, neuroimmunology, and the microbiome. Mostly, however, I trace how his career and interests intertwined with those of Abba J. Kastin and mine and how he exerted a profound i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Neurobiology of Sleep and Circadian Rhythms |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451994425000033 |
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| author | William A. Banks |
| author_facet | William A. Banks |
| author_sort | William A. Banks |
| collection | DOAJ |
| description | In this article for Dr Krueger's Festschrift, I trace how his early career influenced many aspects in the fields of sleep, neuroimmunology, and the microbiome. Mostly, however, I trace how his career and interests intertwined with those of Abba J. Kastin and mine and how he exerted a profound influence on the direction of our studies. Dr. Krueger, while developing his career as a sleep researcher, encountered resistance to his work that required two major paradigm shifts: 1) that bacterial products could affect sleep and 2) that small peptides can cross the blood-brain barrier (BBB) in sufficient amounts to affect brain functioning. Dr Kastin had also shown that small peptides administered peripherally could affect brain function and postulated that this was because they could cross the BBB. Our efforts to determine whether peptides could or could not cross the BBB were bolstered by Dr Krueger's exemplary struggles. |
| format | Article |
| id | doaj-art-b93201d43e5845a3a71d8e0b26d6a960 |
| institution | OA Journals |
| issn | 2451-9944 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Sleep and Circadian Rhythms |
| spelling | doaj-art-b93201d43e5845a3a71d8e0b26d6a9602025-08-20T02:01:46ZengElsevierNeurobiology of Sleep and Circadian Rhythms2451-99442025-05-011810011410.1016/j.nbscr.2025.100114Synergies from a distance: Inspirations from the struggles of Dr James M KruegerWilliam A. Banks0Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USA; 810c/Building 1, 1660 S Columbian Way, GRECC, VAPSHCS, Seattle, WA, 98108, USA.In this article for Dr Krueger's Festschrift, I trace how his early career influenced many aspects in the fields of sleep, neuroimmunology, and the microbiome. Mostly, however, I trace how his career and interests intertwined with those of Abba J. Kastin and mine and how he exerted a profound influence on the direction of our studies. Dr. Krueger, while developing his career as a sleep researcher, encountered resistance to his work that required two major paradigm shifts: 1) that bacterial products could affect sleep and 2) that small peptides can cross the blood-brain barrier (BBB) in sufficient amounts to affect brain functioning. Dr Kastin had also shown that small peptides administered peripherally could affect brain function and postulated that this was because they could cross the BBB. Our efforts to determine whether peptides could or could not cross the BBB were bolstered by Dr Krueger's exemplary struggles.http://www.sciencedirect.com/science/article/pii/S2451994425000033SleepCytokinePeptidesRegulatory proteinsBlood-brain barrier |
| spellingShingle | William A. Banks Synergies from a distance: Inspirations from the struggles of Dr James M Krueger Neurobiology of Sleep and Circadian Rhythms Sleep Cytokine Peptides Regulatory proteins Blood-brain barrier |
| title | Synergies from a distance: Inspirations from the struggles of Dr James M Krueger |
| title_full | Synergies from a distance: Inspirations from the struggles of Dr James M Krueger |
| title_fullStr | Synergies from a distance: Inspirations from the struggles of Dr James M Krueger |
| title_full_unstemmed | Synergies from a distance: Inspirations from the struggles of Dr James M Krueger |
| title_short | Synergies from a distance: Inspirations from the struggles of Dr James M Krueger |
| title_sort | synergies from a distance inspirations from the struggles of dr james m krueger |
| topic | Sleep Cytokine Peptides Regulatory proteins Blood-brain barrier |
| url | http://www.sciencedirect.com/science/article/pii/S2451994425000033 |
| work_keys_str_mv | AT williamabanks synergiesfromadistanceinspirationsfromthestrugglesofdrjamesmkrueger |