Stem Cell Therapy for Treatment of Ocular Disorders
Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degene...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/8304879 |
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| author | Padma Priya Sivan Sakinah Syed Pooi-Ling Mok Akon Higuchi Kadarkarai Murugan Abdullah A. Alarfaj Murugan A. Munusamy Rukman Awang Hamat Akihiro Umezawa Suresh Kumar |
| author_facet | Padma Priya Sivan Sakinah Syed Pooi-Ling Mok Akon Higuchi Kadarkarai Murugan Abdullah A. Alarfaj Murugan A. Munusamy Rukman Awang Hamat Akihiro Umezawa Suresh Kumar |
| author_sort | Padma Priya Sivan |
| collection | DOAJ |
| description | Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degenerated cells despite being present in low quantity and quiescence in our body. Unlike other tissues and cells, regeneration of new optic cells responsible for visual function is rarely observed. Understanding the transcription factors and genes responsible for optic cells development will assist scientists in formulating a strategy to activate and direct stem cells renewal and differentiation. We review the processes of human eye development and address the strategies that have been exploited in an effort to regain visual function in the preclinical and clinical state. The update of clinical findings of patients receiving stem cell treatment is also presented. |
| format | Article |
| id | doaj-art-b931a6cd15d348ca8e1a7070c4e0a960 |
| institution | DOAJ |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b931a6cd15d348ca8e1a7070c4e0a9602025-08-20T03:23:12ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/83048798304879Stem Cell Therapy for Treatment of Ocular DisordersPadma Priya Sivan0Sakinah Syed1Pooi-Ling Mok2Akon Higuchi3Kadarkarai Murugan4Abdullah A. Alarfaj5Murugan A. Munusamy6Rukman Awang Hamat7Akihiro Umezawa8Suresh Kumar9Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaDepartment of Medical Microbiology and Parasitology, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaDepartment of Chemical and Materials Engineering, National Central University, Jhong-li, Taoyuan 32001, TaiwanDivision of Entomology, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, IndiaDepartment of Botany and Microbiology, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Medical Microbiology and Parasitology, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaDepartment of Reproduction, National Research Institute for Child Health and Development, Tokyo 157-8535, JapanDepartment of Medical Microbiology and Parasitology, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, MalaysiaSustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degenerated cells despite being present in low quantity and quiescence in our body. Unlike other tissues and cells, regeneration of new optic cells responsible for visual function is rarely observed. Understanding the transcription factors and genes responsible for optic cells development will assist scientists in formulating a strategy to activate and direct stem cells renewal and differentiation. We review the processes of human eye development and address the strategies that have been exploited in an effort to regain visual function in the preclinical and clinical state. The update of clinical findings of patients receiving stem cell treatment is also presented.http://dx.doi.org/10.1155/2016/8304879 |
| spellingShingle | Padma Priya Sivan Sakinah Syed Pooi-Ling Mok Akon Higuchi Kadarkarai Murugan Abdullah A. Alarfaj Murugan A. Munusamy Rukman Awang Hamat Akihiro Umezawa Suresh Kumar Stem Cell Therapy for Treatment of Ocular Disorders Stem Cells International |
| title | Stem Cell Therapy for Treatment of Ocular Disorders |
| title_full | Stem Cell Therapy for Treatment of Ocular Disorders |
| title_fullStr | Stem Cell Therapy for Treatment of Ocular Disorders |
| title_full_unstemmed | Stem Cell Therapy for Treatment of Ocular Disorders |
| title_short | Stem Cell Therapy for Treatment of Ocular Disorders |
| title_sort | stem cell therapy for treatment of ocular disorders |
| url | http://dx.doi.org/10.1155/2016/8304879 |
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