Evaluation of allergenic properties and immunotoxicity of dipeptide mimetic of brain-derived neurotrophic factor GSB-106

Evaluation of allergenic properties and immunotoxicity of dipeptide mimetic of brain-derived neurotrophic factor GSB-106

Abstract. The study of allergenic properties and immunotoxic effects of the ready-to-use drug form of GSB-106 was carried out. The study of allergenic properties and immunotoxicity of GSB-106 was performed on male albino guinea pigs weighing 250-300 g and on male CBA, C57BL / 6, F1 hybrids (CBAxC57B...

Full description

Saved in:

Bibliographic Details
Main Authors:	L. P. Kovalenko, K. V. Korzhova, R. V. Zhurikov, C. B. Nikitin, A. D. Durnev
Format:	Article
Language:	Russian
Published:	LLC “Publisher OKI” 2020-07-01
Series:	Фармакокинетика и Фармакодинамика
Subjects:	dipeptide mimetic of brain-derived neurotrophic factor gsb-106 phagocytosis chemiluminescence humoral immune response cellular immune response immunotoxicity systemic anaphylaxis delayed hypersensitivity concanavalin а-induced inflammation
Online Access:	https://www.pharmacokinetica.ru/jour/article/view/237
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis and the antidepressant-like activity investigation of bis-(N-monosuccinyl-D-seryl-D-lysine) hexamethylenediamide, the DD-enantiomer of the BDNF dipeptide mimetic, compound GSB-106
by: N. M. Sazonova, et al.
Published: (2024-11-01)

Evaluation of allergenic properties and immunotoxicity of Homeovox
by: L. P. Kovalenko, et al.
Published: (2020-04-01)

Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice
by: A. V. Tallerova, et al.
Published: (2020-04-01)

Pharmacokinetics of dipeptide mimetic BDNF GSB-106 in rats
by: V. P. Zherdev, et al.
Published: (2019-01-01)

The study of the acute and chronic toxicity dipeptide mimetic of brain-derived neurotrophic factor GSB-106 finished dosage form
by: S. V. Alekseeva, et al.
Published: (2019-02-01)

Dimeric dipeptide mimetics of BDNF loop 4 are potential antidepressants with novel mechanisms of action
by: T. A. Gudasheva, et al.
Published: (2025-01-01)

Evaluation of immunotoxicity of the extended-release form of Afobazol
by: L. P. Kovalenko, et al.
Published: (2021-06-01)

Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro
by: I. O. Logvinov, et al.
Published: (2019-10-01)

A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22
by: I. O. Logvinov, et al.
Published: (2017-07-01)

The mimetic of the brain neurotrophic factor GSB-106 has neuroprotective and neuroregenerative effects in experimental ischemic stroke
by: P. Yu. Povarnina, et al.
Published: (2022-05-01)

Evaluation of allergenic properties and immunotoxicity tablet dosage form GML-1 (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazin-3-carboxamide)
by: L. P. Kovalenko, et al.
Published: (2020-12-01)

Screening study of nerve growth factor's and brain-derived neurotrophic factor's mimetics effects at the experimental depression model
by: A. G. Mezhlumyan, et al.
Published: (2020-07-01)

Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology
by: A. V. Tarasiuk, et al.
Published: (2023-01-01)

Cytoprotective properties of the nerve growth factor and brain derived neurotrophic factor dipeptidic mimetics, GK-2 AND GSB-106, in the model of oxidative stress in paramecium caudatum
by: O. V. Karpukhina, et al.
Published: (2018-11-01)

Effect of GK-1 NGF Loop 4 Dipeptide Mimetic on tumor growth and metastasis of Lewis lung carcinoma in experiment on male C57BL/6 mice
by: L. P. Kovalenko, et al.
Published: (2023-05-01)

A study on the mnemotropic and antidepressant-like effects of the low-molecular-weight mimetic of nerve growth factor, dipeptide GK-2, in experimental ischemic stroke
by: P. Yu. Povarnina, et al.
Published: (2024-06-01)

Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GK-2 in rats. Part 2. Kinetics of distribution in organs and tissues
by: G. B. Kolyvanov, et al.
Published: (2024-01-01)

Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics
by: O. Yu. Kravtsova, et al.
Published: (2023-11-01)

Study of the immunotoxic properties of pegylated hyaluronidase
by: K. I. Ershov, et al.
Published: (2023-10-01)

Potential role of vitamin C in mitigating perfluoroalkyl substances-induced immunotoxicity
by: Ruihan Li, et al.
Published: (2025-01-01)

Immunotoxic effects of interferon alpha-2b, modified by immobilization by means of electron-beam synthesis technology
by: D. N. Kinsht, et al.
Published: (2018-01-01)

Estimativas de doses relativas de aplicadores esféricos de 106Ru/106Rh usados em braquiterapia oftalmológica
by: Eduardo De Paiva
Published: (2016-09-01)

Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke
by: P. Y. Povarnina, et al.
Published: (2016-09-01)

Dipeptides in CSF and plasma: diagnostic and therapeutic potential in neurological diseases
by: Katharina Küper, et al.
Published: (2024-12-01)

Immunotoxicity and neurotoxicity induced by natural borneol and synthetic borneol in zebrafish (Danio rerio)
by: Wuting Lu, et al.
Published: (2025-05-01)

Determinação da Distribuição de Dose Absorvida na Água para o Aplicador Oftálmico COC de 106Ru/106Rh Utilizando o Código de Monte Carlo-MCNPX
by: nilseia aparecida barbosa
Published: (2015-05-01)

Acute Toxicity, Neurotoxic, Immunotoxic, and Behavioral Effects of Deltamethrin and Sulfamethoxazole in Adult Zebrafish: Insights into Chemical Interactions and Environmental Implications
by: Yueyue Liu, et al.
Published: (2025-02-01)

Self-Assembled Short Peptide Nanostructures: ‘’Dipeptides’’
by: Mehmet Odabaşı, et al.
Published: (2023-07-01)

Increase in blood-transferable linear and cyclic dipeptides in human plasma following ingestion of elastin hydrolysate
by: Yu Iwasaki, et al.
Published: (2024-12-01)

Radioactive dust with 106Ru over the southern region of Ukraine
by: Yu. A. Tomilin, et al.
Published: (2018-09-01)

Theoretical estimate of relative depth-doses for the asymmetric and spherical 106Ru/106Rh COC-type plaque used in radiotherapy
by: Eduardo De Paiva
Published: (2020-03-01)

Immunotoxicity assessment of multiwalled carbon nanotubes following whole-body inhalation exposure for 30 and 90 days in B6C3F1/N mice and 30 days in HSD:Harlan Sprague Dawley SD® rats
by: Victor J. Johnson, et al.
Published: (2025-05-01)

Assessment of pharmacological safety of a new dipeptide mimetic of the 2nd loop of BDNF when co-administered with ethanol
by: A. V. Nadorova, et al.
Published: (2023-01-01)

The effect of nuclear transcriptional factor κВ activation inhibitor – curcumine on the experimental immune liver disease
by: I. N. Alekseyeva, et al.
Published: (2010-02-01)

Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP
by: Bilin Zhao, et al.
Published: (2025-01-01)

Brain-derived neurotrophic factor and its low-molecular mimetics
by: T. A. Gudasheva, et al.
Published: (2017-07-01)

Assessment of the allergenic and immunotoxic properties of the recombinant non-immunogenic staphylokinase in preclinical and clinical trials
by: S. S. Markin, et al.
Published: (2025-07-01)

Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells
by: T. A. Antipova, et al.
Published: (2017-11-01)

Morphological changes of a retina of an eye at influence by laser radiation of threshold intensity with wavelenght 450 nm and their correction by synthetic dipeptid
by: Ye. Yu. Anikina, et al.
Published: (2009-04-01)

S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk
by: Hao Zheng, et al.
Published: (2025-07-01)