PM2.5-induced oxidative stress upregulates PLA2R expression in the lung and is involved in the pathogenesis of membranous nephropathy through extracellular vesicles

PM2.5-induced oxidative stress upregulates PLA2R expression in the lung and is involved in the pathogenesis of membranous nephropathy through extracellular vesicles

BackgroundParticulate matter (PM2.5) has been implicated in the development of membranous nephropathy (MN), but the underlying mechanism has yet to be fully understood. Oxidative stress is an essential factor of PM2.5-related toxicity and plays a significant role in the exposure of target antigenic...

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Bibliographic Details
Main Authors: Wang Zhang, Jiating Chen, Ye Yuan, Jiao Luo, Zhanmei Zhou, Guobao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
oxidative stress
membranous nephropathy
extracellular vesicles
PM 2.5
PLA2R
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1516111/full
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