Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the pulmonary fibrosis in microscopic polyangiitis with anti-myeloperoxidase antibodies and rheumatoid factor. Literature review and own observation
Depending on the epitope specificity of antineutrophil cytoplasmic antibodies (ANCA) and the presence or absence of a granulomatous inflammation. Patients with ANCA-associated vasculitis (AAV) show variability in clinical manifestations and prognosis depending on the epitope specificity of ANCA and...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2023-03-01
|
| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/3279 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849687891530219520 |
|---|---|
| author | T. V. Beketova O. A. Golovina A. S. Avdeeva |
| author_facet | T. V. Beketova O. A. Golovina A. S. Avdeeva |
| author_sort | T. V. Beketova |
| collection | DOAJ |
| description | Depending on the epitope specificity of antineutrophil cytoplasmic antibodies (ANCA) and the presence or absence of a granulomatous inflammation. Patients with ANCA-associated vasculitis (AAV) show variability in clinical manifestations and prognosis depending on the epitope specificity of ANCA and the presence or absence of granulomatous inflammation. In this regard, it is important to identify the clinical and immunological phenotypes of AAV and a personalized approach to treatment. Microscopic polyangiitis (MPA) with antibodies to myeloperoxidase (aMPO) has a relatively high incidence of lung involvement and pulmonary fibrosis. We present our own clinical case of pulmonary fibrosis in MPA with aMPO and rheumatoid factor. Literature data are discussed. In cases of early arthritis and interstitial pneumonia, the possibility of AAV should be considered, a detailed examination is necessary to identify pathognomonic signs of AAV, including asymptomatic ones. Before prescribing immunosuppressants, the epitope specificity of ANCA should be determined. Treatment with rituximab, mycophenolate mofetil and nintedanib is discussed. |
| format | Article |
| id | doaj-art-b92dbf8073dc42259430ea84fdca767c |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-b92dbf8073dc42259430ea84fdca767c2025-08-20T03:22:12ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922023-03-01611626910.47360/1995-4484-2023-62-692876Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the pulmonary fibrosis in microscopic polyangiitis with anti-myeloperoxidase antibodies and rheumatoid factor. Literature review and own observationT. V. Beketova0O. A. Golovina1A. S. Avdeeva2V.A. Nasonova Research Institute of Rheumatology; Central Clinical Hospital of the Administrative Directorate of the President of the Russian Federation; Moscow Polytechnic UniversityV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyDepending on the epitope specificity of antineutrophil cytoplasmic antibodies (ANCA) and the presence or absence of a granulomatous inflammation. Patients with ANCA-associated vasculitis (AAV) show variability in clinical manifestations and prognosis depending on the epitope specificity of ANCA and the presence or absence of granulomatous inflammation. In this regard, it is important to identify the clinical and immunological phenotypes of AAV and a personalized approach to treatment. Microscopic polyangiitis (MPA) with antibodies to myeloperoxidase (aMPO) has a relatively high incidence of lung involvement and pulmonary fibrosis. We present our own clinical case of pulmonary fibrosis in MPA with aMPO and rheumatoid factor. Literature data are discussed. In cases of early arthritis and interstitial pneumonia, the possibility of AAV should be considered, a detailed examination is necessary to identify pathognomonic signs of AAV, including asymptomatic ones. Before prescribing immunosuppressants, the epitope specificity of ANCA should be determined. Treatment with rituximab, mycophenolate mofetil and nintedanib is discussed.https://rsp.mediar-press.net/rsp/article/view/3279anca-associated vasculitismicroscopic polyangiitisanti-myeloperoxidase antibodypulmonary fibrosisrheumatoid arthritisrheumatoid factorantibodies to cyclic citrullinated peptide |
| spellingShingle | T. V. Beketova O. A. Golovina A. S. Avdeeva Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the pulmonary fibrosis in microscopic polyangiitis with anti-myeloperoxidase antibodies and rheumatoid factor. Literature review and own observation Научно-практическая ревматология anca-associated vasculitis microscopic polyangiitis anti-myeloperoxidase antibody pulmonary fibrosis rheumatoid arthritis rheumatoid factor antibodies to cyclic citrullinated peptide |
| title | Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the pulmonary fibrosis in microscopic polyangiitis with anti-myeloperoxidase antibodies and rheumatoid factor. Literature review and own observation |
| title_full | Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the pulmonary fibrosis in microscopic polyangiitis with anti-myeloperoxidase antibodies and rheumatoid factor. Literature review and own observation |
| title_fullStr | Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the pulmonary fibrosis in microscopic polyangiitis with anti-myeloperoxidase antibodies and rheumatoid factor. Literature review and own observation |
| title_full_unstemmed | Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the pulmonary fibrosis in microscopic polyangiitis with anti-myeloperoxidase antibodies and rheumatoid factor. Literature review and own observation |
| title_short | Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the pulmonary fibrosis in microscopic polyangiitis with anti-myeloperoxidase antibodies and rheumatoid factor. Literature review and own observation |
| title_sort | clinical and immunological variants of anca associated systemic vasculitis a look at the pulmonary fibrosis in microscopic polyangiitis with anti myeloperoxidase antibodies and rheumatoid factor literature review and own observation |
| topic | anca-associated vasculitis microscopic polyangiitis anti-myeloperoxidase antibody pulmonary fibrosis rheumatoid arthritis rheumatoid factor antibodies to cyclic citrullinated peptide |
| url | https://rsp.mediar-press.net/rsp/article/view/3279 |
| work_keys_str_mv | AT tvbeketova clinicalandimmunologicalvariantsofancaassociatedsystemicvasculitisalookatthepulmonaryfibrosisinmicroscopicpolyangiitiswithantimyeloperoxidaseantibodiesandrheumatoidfactorliteraturereviewandownobservation AT oagolovina clinicalandimmunologicalvariantsofancaassociatedsystemicvasculitisalookatthepulmonaryfibrosisinmicroscopicpolyangiitiswithantimyeloperoxidaseantibodiesandrheumatoidfactorliteraturereviewandownobservation AT asavdeeva clinicalandimmunologicalvariantsofancaassociatedsystemicvasculitisalookatthepulmonaryfibrosisinmicroscopicpolyangiitiswithantimyeloperoxidaseantibodiesandrheumatoidfactorliteraturereviewandownobservation |