Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases
The aim of review. To prove competency of application of probiotics and to analyze data of the original studies of efficacy of various probiotic agents in treatment of inflammatory bowel diseases (IBD).Summary. The role of microflora in pathogenesis of this group of diseases becomes more and more ob...
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| Language: | Russian |
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Gastro LLC
2015-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1002 |
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| author | Ye. A. Poluektova Yu. O. Sidorina S. Yu. Kuchumova A. V. Korolev O. S. Shifrin |
| author_facet | Ye. A. Poluektova Yu. O. Sidorina S. Yu. Kuchumova A. V. Korolev O. S. Shifrin |
| author_sort | Ye. A. Poluektova |
| collection | DOAJ |
| description | The aim of review. To prove competency of application of probiotics and to analyze data of the original studies of efficacy of various probiotic agents in treatment of inflammatory bowel diseases (IBD).Summary. The role of microflora in pathogenesis of this group of diseases becomes more and more obvious. At patients with IBD the intestinal microbiome have quantitative and qualitative differences from microbiome of healthy patients aside of increase in contents of opportunistic and pathogenic microorganisms. Microbiome changes result in initiation of cascade of pathological immune reactions of the host in related to presence of genetical defects, that, in turn, promotes development of clinical symptoms and morphological changes in intestinal wall. Potential of probiotic agents effect on microflora is actively studied in the last years, including patients with IBD.Conclusion. The highest efficacy the Bifidum and Lactobacilli-containing probiotics, possess at advance and maintenance of remission of reservoir ileitis (pouchitis). Addition of probiotics in mode of treatment significantly increases probability of clinical improvement and, at level of the statistical trend, achievement of clinical remission at ulcerative colitis. In remission maintenance efficacy of the studied probiotic drugs is comparable to efficacy of maintenance dozes of mesalazine. Efficacy of probiotics is not proved at their addition in the mode of standard therapy used for achievement and maintenance of remission of a Crohn's disease. |
| format | Article |
| id | doaj-art-b926a27d70a24b9793ed13525cb6c353 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-b926a27d70a24b9793ed13525cb6c3532025-02-10T16:14:33ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-05-012525868610Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseasesYe. A. Poluektova0Yu. O. Sidorina1S. Yu. Kuchumova2A. V. Korolev3O. S. Shifrin45State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»ГБОУ ВПО «Первый Московский государственный медицинский университет им И. М. Сеченова» Минздрава РоссииThe aim of review. To prove competency of application of probiotics and to analyze data of the original studies of efficacy of various probiotic agents in treatment of inflammatory bowel diseases (IBD).Summary. The role of microflora in pathogenesis of this group of diseases becomes more and more obvious. At patients with IBD the intestinal microbiome have quantitative and qualitative differences from microbiome of healthy patients aside of increase in contents of opportunistic and pathogenic microorganisms. Microbiome changes result in initiation of cascade of pathological immune reactions of the host in related to presence of genetical defects, that, in turn, promotes development of clinical symptoms and morphological changes in intestinal wall. Potential of probiotic agents effect on microflora is actively studied in the last years, including patients with IBD.Conclusion. The highest efficacy the Bifidum and Lactobacilli-containing probiotics, possess at advance and maintenance of remission of reservoir ileitis (pouchitis). Addition of probiotics in mode of treatment significantly increases probability of clinical improvement and, at level of the statistical trend, achievement of clinical remission at ulcerative colitis. In remission maintenance efficacy of the studied probiotic drugs is comparable to efficacy of maintenance dozes of mesalazine. Efficacy of probiotics is not proved at their addition in the mode of standard therapy used for achievement and maintenance of remission of a Crohn's disease.https://www.gastro-j.ru/jour/article/view/1002probioticsmicrobiomeinflammatory bowel diseasesulcerative colitiscrohn's diseasepouchitis |
| spellingShingle | Ye. A. Poluektova Yu. O. Sidorina S. Yu. Kuchumova A. V. Korolev O. S. Shifrin Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases Российский журнал гастроэнтерологии, гепатологии, колопроктологии probiotics microbiome inflammatory bowel diseases ulcerative colitis crohn's disease pouchitis |
| title | Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases |
| title_full | Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases |
| title_fullStr | Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases |
| title_full_unstemmed | Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases |
| title_short | Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases |
| title_sort | substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases |
| topic | probiotics microbiome inflammatory bowel diseases ulcerative colitis crohn's disease pouchitis |
| url | https://www.gastro-j.ru/jour/article/view/1002 |
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