Safety and Technical Success of CT-Guided Bone Marrow Biopsy in Obese Patients
Purpose Obesity can make bone marrow biopsy using manual landmarks as guidance technically challenging. This retrospective review was performed to assess the safety and technical success of performing bone marrow biopsies with computed tomography (CT)–guidance in obese patients. Materials and Metho...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-04-01
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| Series: | Journal of Clinical Interventional Radiology ISVIR |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-3401330 |
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| author | Barbara Manchec Joseph Limback Bo Liu Julie W Pepe Jeremy Burt Francisco Contreras Thomas J. Ward |
| author_facet | Barbara Manchec Joseph Limback Bo Liu Julie W Pepe Jeremy Burt Francisco Contreras Thomas J. Ward |
| author_sort | Barbara Manchec |
| collection | DOAJ |
| description | Purpose Obesity can make bone marrow biopsy using manual landmarks as guidance technically challenging. This retrospective review was performed to assess the safety and technical success of performing bone marrow biopsies with computed tomography (CT)–guidance in obese patients.
Materials and Methods This single-institution, retrospective study included 1,016 CT-guided bone marrow biopsies performed between 2009 and 2016. Thirty-four percent (n = 348) were performed in patients with a body mass index (BMI) of 30 kg/m2 or greater, and 7% (n = 75) were performed in patients with a BMI greater than 40 kg/m2. Demographic information, BMI, and complications were reviewed. The primary endpoint was technical success and procedurally related hemorrhagic complication. The electronic medical record was reviewed to identify procedural related hemorrhagic complications, Common Terminology Criteria for Adverse Events (CTCAE) Grade 3 or above. The complication rates in obese patients were compared with patients with a BMI less than 30 kg/m2.
Results Biopsy was successfully performed in all patients. No biopsies resulted in a CTCAE Grade 3 or above complication. There was no difference in complication rate (0%) based on BMI. For patients with a BMI < 30 kg/m2, BMI ≥ 30 kg/m2, and BMI > 40 kg/m2, complications rates were 0% (95% confidence interval [CI]: 0–0.4%), 0% (95% CI: 0–0.9%), and 0% (95% CI: 0–4%), respectively.
Conclusions CT-guided bone marrow biopsy in obese patients can be performed with a high rate of technical success and is safe. If patient body habitus limits the ability to palpate physical landmarks needed to perform bone marrow biopsy without image guidance, CT-guided bone marrow biopsy should be considered. |
| format | Article |
| id | doaj-art-b9237c70e6fa4d4ca1ad9ad27dadb254 |
| institution | OA Journals |
| issn | 2456-4869 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Clinical Interventional Radiology ISVIR |
| spelling | doaj-art-b9237c70e6fa4d4ca1ad9ad27dadb2542025-08-20T02:23:39ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Clinical Interventional Radiology ISVIR2456-48692020-04-01401161910.1055/s-0039-3401330Safety and Technical Success of CT-Guided Bone Marrow Biopsy in Obese PatientsBarbara Manchec0Joseph Limback1Bo Liu2Julie W Pepe3Jeremy Burt4Francisco Contreras5Thomas J. Ward6Department of Radiology, Advent Health, Orlando, Florida, United StatesDepartment of Radiology, Advent Health, Orlando, Florida, United StatesMiami Cardiac and Vascular Institute, Miami, Florida, United StatesCenter for Collaborative Research, Advent Health, Orlando, Florida, United StatesDepartment of Radiology, Advent Health, Orlando, Florida, United StatesDepartment of Radiology, Advent Health, Orlando, Florida, United StatesDepartment of Radiology, Advent Health, Orlando, Florida, United StatesPurpose Obesity can make bone marrow biopsy using manual landmarks as guidance technically challenging. This retrospective review was performed to assess the safety and technical success of performing bone marrow biopsies with computed tomography (CT)–guidance in obese patients. Materials and Methods This single-institution, retrospective study included 1,016 CT-guided bone marrow biopsies performed between 2009 and 2016. Thirty-four percent (n = 348) were performed in patients with a body mass index (BMI) of 30 kg/m2 or greater, and 7% (n = 75) were performed in patients with a BMI greater than 40 kg/m2. Demographic information, BMI, and complications were reviewed. The primary endpoint was technical success and procedurally related hemorrhagic complication. The electronic medical record was reviewed to identify procedural related hemorrhagic complications, Common Terminology Criteria for Adverse Events (CTCAE) Grade 3 or above. The complication rates in obese patients were compared with patients with a BMI less than 30 kg/m2. Results Biopsy was successfully performed in all patients. No biopsies resulted in a CTCAE Grade 3 or above complication. There was no difference in complication rate (0%) based on BMI. For patients with a BMI < 30 kg/m2, BMI ≥ 30 kg/m2, and BMI > 40 kg/m2, complications rates were 0% (95% confidence interval [CI]: 0–0.4%), 0% (95% CI: 0–0.9%), and 0% (95% CI: 0–4%), respectively. Conclusions CT-guided bone marrow biopsy in obese patients can be performed with a high rate of technical success and is safe. If patient body habitus limits the ability to palpate physical landmarks needed to perform bone marrow biopsy without image guidance, CT-guided bone marrow biopsy should be considered.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-3401330bone marrow examinationimage-guided biopsyobesity |
| spellingShingle | Barbara Manchec Joseph Limback Bo Liu Julie W Pepe Jeremy Burt Francisco Contreras Thomas J. Ward Safety and Technical Success of CT-Guided Bone Marrow Biopsy in Obese Patients Journal of Clinical Interventional Radiology ISVIR bone marrow examination image-guided biopsy obesity |
| title | Safety and Technical Success of CT-Guided Bone Marrow Biopsy in Obese Patients |
| title_full | Safety and Technical Success of CT-Guided Bone Marrow Biopsy in Obese Patients |
| title_fullStr | Safety and Technical Success of CT-Guided Bone Marrow Biopsy in Obese Patients |
| title_full_unstemmed | Safety and Technical Success of CT-Guided Bone Marrow Biopsy in Obese Patients |
| title_short | Safety and Technical Success of CT-Guided Bone Marrow Biopsy in Obese Patients |
| title_sort | safety and technical success of ct guided bone marrow biopsy in obese patients |
| topic | bone marrow examination image-guided biopsy obesity |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-3401330 |
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