On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy
The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2012/140284 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850159440660004864 |
|---|---|
| author | Santiago Gómez-Ruiz Danijela Maksimović-Ivanić Sanja Mijatović Goran N. Kaluđerović |
| author_facet | Santiago Gómez-Ruiz Danijela Maksimović-Ivanić Sanja Mijatović Goran N. Kaluđerović |
| author_sort | Santiago Gómez-Ruiz |
| collection | DOAJ |
| description | The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity. |
| format | Article |
| id | doaj-art-b91e5c0adb8445d98a35d8fd2d14bb2c |
| institution | OA Journals |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-b91e5c0adb8445d98a35d8fd2d14bb2c2025-08-20T02:23:32ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2012-01-01201210.1155/2012/140284140284On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer ChemotherapySantiago Gómez-Ruiz0Danijela Maksimović-Ivanić1Sanja Mijatović2Goran N. Kaluđerović3Departamento de Química Inorgánica y Analítica, E.S.C.E.T., Universidad Rey Juan Carlos, 28933 Móstoles, SpainInstitute for Biological Research “Sinisa Stankovic”, University of Belgrade, Boulevard of Despot Stefan 142, 11060 Belgrade, SerbiaInstitute for Biological Research “Sinisa Stankovic”, University of Belgrade, Boulevard of Despot Stefan 142, 11060 Belgrade, SerbiaInstitut für Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Straße 2, 06120 Halle, GermanyThe purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.http://dx.doi.org/10.1155/2012/140284 |
| spellingShingle | Santiago Gómez-Ruiz Danijela Maksimović-Ivanić Sanja Mijatović Goran N. Kaluđerović On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy Bioinorganic Chemistry and Applications |
| title | On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy |
| title_full | On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy |
| title_fullStr | On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy |
| title_full_unstemmed | On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy |
| title_short | On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy |
| title_sort | on the discovery biological effects and use of cisplatin and metallocenes in anticancer chemotherapy |
| url | http://dx.doi.org/10.1155/2012/140284 |
| work_keys_str_mv | AT santiagogomezruiz onthediscoverybiologicaleffectsanduseofcisplatinandmetallocenesinanticancerchemotherapy AT danijelamaksimovicivanic onthediscoverybiologicaleffectsanduseofcisplatinandmetallocenesinanticancerchemotherapy AT sanjamijatovic onthediscoverybiologicaleffectsanduseofcisplatinandmetallocenesinanticancerchemotherapy AT gorannkaluđerovic onthediscoverybiologicaleffectsanduseofcisplatinandmetallocenesinanticancerchemotherapy |