The Safety and Efficacy of Glibenclamide in Managing Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

The Safety and Efficacy of Glibenclamide in Managing Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

Background/Objectives: We sought to determine if glibenclamide, a sulfonylurea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) channel blocker, reduces cerebral edema and improves neurological functioning in aneurysmal subarachnoid hemorrhage (aSAH). Methods: Following Preferred Re...

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Bibliographic Details
Main Authors: Majd M. AlBarakat, Rana B. Altawalbeh, Khaled Mohamed Hamam, Ahmed A. Lashin, Ahmed Wadaa-Allah, Ayah J. Alkrarha, Mohamed Abuelazm, James Robert Brašić
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Brain Sciences
Subjects:
calcium channel blocker
clinical trials
endothelium
functional independence
hypoglycemia
morbidity
Online Access:https://www.mdpi.com/2076-3425/15/7/677
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