Targeted regeneration of bone in the osteoporotic human femur.
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. A...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016190&type=printable |
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| _version_ | 1849725843403702272 |
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| author | Kenneth E S Poole Graham M Treece Gerard R Ridgway Paul M Mayhew Jan Borggrefe Andrew H Gee |
| author_facet | Kenneth E S Poole Graham M Treece Gerard R Ridgway Paul M Mayhew Jan Borggrefe Andrew H Gee |
| author_sort | Kenneth E S Poole |
| collection | DOAJ |
| description | We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness. |
| format | Article |
| id | doaj-art-b91e25f2aacd4cf488b6c9446dc876b6 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b91e25f2aacd4cf488b6c9446dc876b62025-08-20T03:10:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0161e1619010.1371/journal.pone.0016190Targeted regeneration of bone in the osteoporotic human femur.Kenneth E S PooleGraham M TreeceGerard R RidgwayPaul M MayhewJan BorggrefeAndrew H GeeWe have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016190&type=printable |
| spellingShingle | Kenneth E S Poole Graham M Treece Gerard R Ridgway Paul M Mayhew Jan Borggrefe Andrew H Gee Targeted regeneration of bone in the osteoporotic human femur. PLoS ONE |
| title | Targeted regeneration of bone in the osteoporotic human femur. |
| title_full | Targeted regeneration of bone in the osteoporotic human femur. |
| title_fullStr | Targeted regeneration of bone in the osteoporotic human femur. |
| title_full_unstemmed | Targeted regeneration of bone in the osteoporotic human femur. |
| title_short | Targeted regeneration of bone in the osteoporotic human femur. |
| title_sort | targeted regeneration of bone in the osteoporotic human femur |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016190&type=printable |
| work_keys_str_mv | AT kennethespoole targetedregenerationofboneintheosteoporotichumanfemur AT grahammtreece targetedregenerationofboneintheosteoporotichumanfemur AT gerardrridgway targetedregenerationofboneintheosteoporotichumanfemur AT paulmmayhew targetedregenerationofboneintheosteoporotichumanfemur AT janborggrefe targetedregenerationofboneintheosteoporotichumanfemur AT andrewhgee targetedregenerationofboneintheosteoporotichumanfemur |