Over-expression and increased copy numbers of a cytochrome P450 and two UDP-glucuronosyltransferase genes in macrocyclic lactone resistant Psoroptes ovis of cattle.

Over-expression and increased copy numbers of a cytochrome P450 and two UDP-glucuronosyltransferase genes in macrocyclic lactone resistant Psoroptes ovis of cattle.

Psoroptes ovis is a mite species that feeds on sheep, cattle, other ungulates, rabbits, and horses, which can develop into a severe exudative dermatitis known as psoroptic mange. The macrocyclic lactone (ML) family of acaricides are commonly used to control psoroptic mange. However, certain strains...

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Main Authors: Jack Hearn, Wouter van Mol, Roel Meyermans, Kathryn Bartley, Tyler Alioto, Jèssica Gómez-Garrido, Fernando Cruz, Francisco Câmara Ferreira, Marta Gut, Ivo G Gut, Nadine Buys, Steven Janssens, Karyn Adams, Sara Roose, Thomas Van Leeuwen, Wannes Dermauw, John S Gilleard, Russell W Avramenko, Peter Geldhof, Edwin Claerebout, Stewart T G Burgess
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012963
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