A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine
ABSTRACT Background It is believed that vitamin B12 deficiency and hyperhomocysteinemia cause endothelial cell damage by increasing the levels of free oxygen radicals, which may, in turn, be related to the onset of migraine episodes. Objective The objective of our study was to ascertain a correl...
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Thieme Revinter Publicações
2022-08-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000600586&tlng=en |
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| author | Sibel Üstün Özek |
| author_facet | Sibel Üstün Özek |
| author_sort | Sibel Üstün Özek |
| collection | DOAJ |
| description | ABSTRACT Background It is believed that vitamin B12 deficiency and hyperhomocysteinemia cause endothelial cell damage by increasing the levels of free oxygen radicals, which may, in turn, be related to the onset of migraine episodes. Objective The objective of our study was to ascertain a correlation between vitamin B12 levels and migraine attack frequency and pain severity. Methods 127 patients with migraine and 45 healthy controls who presented to Okmeydanı Training and Research Hospital were included in the study. The migraine attack frequency and the duration and severity of pain in migraineurs were recorded. Pain severity was evaluated using a visual analogue scale (VAS). Vitamin B12 levels below 300 ng/L were considered low. Results The vitamin B12 levels in migraineurs were found to be significantly lower than those in the control group (227.30 ± 104.72 ng/L vs 278.44 ± 149.83 ng/L; p = 0.047). The vitamin B12 levels of patients with chronic migraine (CM) were found to be lower than those in patients with less frequent migraine attacks (197.50 ± 69.16 ng/L vs 278.56 ± 147.91 ng/L; p = 0.019). The ratio of vitamin B12 levels of 300 ng/L and above in patients with CM was lower than that of patients with episodic migraine (p < 0.05). Conclusions Along with attack frequency and pain severity assessment, it is important that migraine follow-ups should include regular measurement of vitamin B12 levels. We found lower vitamin B12 values in the CM group. |
| format | Article |
| id | doaj-art-b917f3423abb4ee1aa718e575fbd56f8 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-b917f3423abb4ee1aa718e575fbd56f82025-08-20T03:04:48ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272022-08-0180658659210.1590/0004-282x-anp-2021-0192A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraineSibel Üstün Özekhttps://orcid.org/0000-0003-1165-2648ABSTRACT Background It is believed that vitamin B12 deficiency and hyperhomocysteinemia cause endothelial cell damage by increasing the levels of free oxygen radicals, which may, in turn, be related to the onset of migraine episodes. Objective The objective of our study was to ascertain a correlation between vitamin B12 levels and migraine attack frequency and pain severity. Methods 127 patients with migraine and 45 healthy controls who presented to Okmeydanı Training and Research Hospital were included in the study. The migraine attack frequency and the duration and severity of pain in migraineurs were recorded. Pain severity was evaluated using a visual analogue scale (VAS). Vitamin B12 levels below 300 ng/L were considered low. Results The vitamin B12 levels in migraineurs were found to be significantly lower than those in the control group (227.30 ± 104.72 ng/L vs 278.44 ± 149.83 ng/L; p = 0.047). The vitamin B12 levels of patients with chronic migraine (CM) were found to be lower than those in patients with less frequent migraine attacks (197.50 ± 69.16 ng/L vs 278.56 ± 147.91 ng/L; p = 0.019). The ratio of vitamin B12 levels of 300 ng/L and above in patients with CM was lower than that of patients with episodic migraine (p < 0.05). Conclusions Along with attack frequency and pain severity assessment, it is important that migraine follow-ups should include regular measurement of vitamin B12 levels. We found lower vitamin B12 values in the CM group.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000600586&tlng=enMigraine DisordersHeadache, Vitamin B 12Homocysteine |
| spellingShingle | Sibel Üstün Özek A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine Arquivos de Neuro-Psiquiatria Migraine Disorders Headache, Vitamin B 12 Homocysteine |
| title | A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine |
| title_full | A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine |
| title_fullStr | A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine |
| title_full_unstemmed | A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine |
| title_short | A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine |
| title_sort | study on the correlation between pain frequency and severity and vitamin b12 levels in episodic and chronic migraine |
| topic | Migraine Disorders Headache, Vitamin B 12 Homocysteine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000600586&tlng=en |
| work_keys_str_mv | AT sibelustunozek astudyonthecorrelationbetweenpainfrequencyandseverityandvitaminb12levelsinepisodicandchronicmigraine AT sibelustunozek studyonthecorrelationbetweenpainfrequencyandseverityandvitaminb12levelsinepisodicandchronicmigraine |