Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions.
Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodolog...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-09-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005888&type=printable |
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| author | Rhea J Longley Michael T White Eizo Takashima Masayuki Morita Bernard N Kanoi Connie S N Li Wai Suen Inoni Betuela Andrea Kuehn Piyarat Sripoorote Camila T Franca Peter Siba Leanne J Robinson Marcus Lacerda Jetsumon Sattabongkot Takafumi Tsuboi Ivo Mueller |
| author_facet | Rhea J Longley Michael T White Eizo Takashima Masayuki Morita Bernard N Kanoi Connie S N Li Wai Suen Inoni Betuela Andrea Kuehn Piyarat Sripoorote Camila T Franca Peter Siba Leanne J Robinson Marcus Lacerda Jetsumon Sattabongkot Takafumi Tsuboi Ivo Mueller |
| author_sort | Rhea J Longley |
| collection | DOAJ |
| description | Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein. |
| format | Article |
| id | doaj-art-b90261fd6e3e4c2c915a3a58f93fc7ba |
| institution | DOAJ |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-b90261fd6e3e4c2c915a3a58f93fc7ba2025-08-20T02:45:30ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352017-09-01119e000588810.1371/journal.pntd.0005888Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions.Rhea J LongleyMichael T WhiteEizo TakashimaMasayuki MoritaBernard N KanoiConnie S N Li Wai SuenInoni BetuelaAndrea KuehnPiyarat SripooroteCamila T FrancaPeter SibaLeanne J RobinsonMarcus LacerdaJetsumon SattabongkotTakafumi TsuboiIvo MuellerPlasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005888&type=printable |
| spellingShingle | Rhea J Longley Michael T White Eizo Takashima Masayuki Morita Bernard N Kanoi Connie S N Li Wai Suen Inoni Betuela Andrea Kuehn Piyarat Sripoorote Camila T Franca Peter Siba Leanne J Robinson Marcus Lacerda Jetsumon Sattabongkot Takafumi Tsuboi Ivo Mueller Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. PLoS Neglected Tropical Diseases |
| title | Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. |
| title_full | Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. |
| title_fullStr | Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. |
| title_full_unstemmed | Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. |
| title_short | Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. |
| title_sort | naturally acquired antibody responses to more than 300 plasmodium vivax proteins in three geographic regions |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005888&type=printable |
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