Primary amelanotic malignant melanoma of the esophagus: a case report
Abstract Background Primary amelanotic malignant melanoma of esophagus, which is a subtype of primary malignant melanoma of the esophagus (PMME), is a very rare disease with a poor prognosis. We herein report a case of the amelanotic type of PMME. Case presentation An 86-year-old woman was admitted...
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| Language: | English |
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Japan Surgical Society
2019-01-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-019-0564-2 |
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| author | Naomichi Koga Nobuhide Kubo Hiroshi Saeki Shun Sasaki Tomoko Jogo Kosuke Hirose Yuichiro Nakashima Eiji Oki Yutaka Koga Yoshinao Oda Hisao Oiwa Toshio Oiwa Yoshihiko Maehara |
| author_facet | Naomichi Koga Nobuhide Kubo Hiroshi Saeki Shun Sasaki Tomoko Jogo Kosuke Hirose Yuichiro Nakashima Eiji Oki Yutaka Koga Yoshinao Oda Hisao Oiwa Toshio Oiwa Yoshihiko Maehara |
| author_sort | Naomichi Koga |
| collection | DOAJ |
| description | Abstract Background Primary amelanotic malignant melanoma of esophagus, which is a subtype of primary malignant melanoma of the esophagus (PMME), is a very rare disease with a poor prognosis. We herein report a case of the amelanotic type of PMME. Case presentation An 86-year-old woman was admitted to our hospital with symptoms of dysphagia. An endoscopic examination and constructed radiography revealed an elevated and semipedunculated lesion with an ulcer in the lower thoracic esophagus accompanied by another submucosal lesion of the esophagus. She was diagnosed with esophageal squamous cell carcinoma by a preoperative endoscopic biopsy. We performed thoracoscopy- and laparoscopy-assisted subtotal esophagectomy with lymphadenectomy. Based on the surgical specimens, although there were no melanocytes, we made a diagnosis of a malignant melanoma immunohistochemically; the tumor cells were positive for S-100 protein and HMB45 focally and partially for Melan-A. Conclusion We experienced a case of primary amelanotic malignant melanoma, and the patient has remained disease-free for 1 year since the surgery. Since the diagnosis of amelanotic type of PMME is difficult, it should be made by the combination of a morphological examination, pathological examination, and immunohistochemistry. |
| format | Article |
| id | doaj-art-b8fffe8c22d14e6aac40e95272f2e57f |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-b8fffe8c22d14e6aac40e95272f2e57f2025-08-20T03:57:47ZengJapan Surgical SocietySurgical Case Reports2198-77932019-01-01511610.1186/s40792-019-0564-2Primary amelanotic malignant melanoma of the esophagus: a case reportNaomichi Koga0Nobuhide Kubo1Hiroshi Saeki2Shun Sasaki3Tomoko Jogo4Kosuke Hirose5Yuichiro Nakashima6Eiji Oki7Yutaka Koga8Yoshinao Oda9Hisao Oiwa10Toshio Oiwa11Yoshihiko Maehara12Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu UniversityOiwa Gastrointestinal ClinicOiwa Gastrointestinal ClinicKyushu Central Hospital of the Mutual Aid Association of Public School TeachersAbstract Background Primary amelanotic malignant melanoma of esophagus, which is a subtype of primary malignant melanoma of the esophagus (PMME), is a very rare disease with a poor prognosis. We herein report a case of the amelanotic type of PMME. Case presentation An 86-year-old woman was admitted to our hospital with symptoms of dysphagia. An endoscopic examination and constructed radiography revealed an elevated and semipedunculated lesion with an ulcer in the lower thoracic esophagus accompanied by another submucosal lesion of the esophagus. She was diagnosed with esophageal squamous cell carcinoma by a preoperative endoscopic biopsy. We performed thoracoscopy- and laparoscopy-assisted subtotal esophagectomy with lymphadenectomy. Based on the surgical specimens, although there were no melanocytes, we made a diagnosis of a malignant melanoma immunohistochemically; the tumor cells were positive for S-100 protein and HMB45 focally and partially for Melan-A. Conclusion We experienced a case of primary amelanotic malignant melanoma, and the patient has remained disease-free for 1 year since the surgery. Since the diagnosis of amelanotic type of PMME is difficult, it should be made by the combination of a morphological examination, pathological examination, and immunohistochemistry.http://link.springer.com/article/10.1186/s40792-019-0564-2EsophagusAmelanotic melanomaDiagnosisPrognosisPathology |
| spellingShingle | Naomichi Koga Nobuhide Kubo Hiroshi Saeki Shun Sasaki Tomoko Jogo Kosuke Hirose Yuichiro Nakashima Eiji Oki Yutaka Koga Yoshinao Oda Hisao Oiwa Toshio Oiwa Yoshihiko Maehara Primary amelanotic malignant melanoma of the esophagus: a case report Surgical Case Reports Esophagus Amelanotic melanoma Diagnosis Prognosis Pathology |
| title | Primary amelanotic malignant melanoma of the esophagus: a case report |
| title_full | Primary amelanotic malignant melanoma of the esophagus: a case report |
| title_fullStr | Primary amelanotic malignant melanoma of the esophagus: a case report |
| title_full_unstemmed | Primary amelanotic malignant melanoma of the esophagus: a case report |
| title_short | Primary amelanotic malignant melanoma of the esophagus: a case report |
| title_sort | primary amelanotic malignant melanoma of the esophagus a case report |
| topic | Esophagus Amelanotic melanoma Diagnosis Prognosis Pathology |
| url | http://link.springer.com/article/10.1186/s40792-019-0564-2 |
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