Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin Delivery
The present study involved the synthesis of a bioactive composite material using chitosan (CS) and multi-walled carbon nanotubes (MWCNTs) through the free radical polymerization method. The resulting composite material was comprehensively characterized using various experimental techniques, such as...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2024-12-01
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| Series: | Indonesian Journal of Chemistry |
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| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/97160 |
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| author | Zainab Jasim Khudair Zeina Mohammad Kadam |
| author_facet | Zainab Jasim Khudair Zeina Mohammad Kadam |
| author_sort | Zainab Jasim Khudair |
| collection | DOAJ |
| description | The present study involved the synthesis of a bioactive composite material using chitosan (CS) and multi-walled carbon nanotubes (MWCNTs) through the free radical polymerization method. The resulting composite material was comprehensively characterized using various experimental techniques, such as Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The quantification of the swelling behavior involved the measurement of changes in the weight of the sample as a function of the time it was immersed in an aqueous buffered solution. The findings indicated that the maximum drug-loading rate of ofloxacin medication (OFL) was 86%. Moreover, the pH sensitivity of the poly acrylic acid grafting multi-walled carbon nanotubes p(CS-co-AA)/MWCNTs nanocomposite facilitated the substantial release of a significant quantity of medication in aqueous buffered solution at a pH of 1.2. The average rate of drug release was measured to be 76% after 72 h duration. On the other hand, the release of the drug at pH 5 and 7.4 was 42% and 32%, respectively. According to the reported findings, the p(CS-co-AA)/MWCNTs carrier has a favorable capacity to control the release of the OFL drug into the intended medium while reducing potential negative effects. |
| format | Article |
| id | doaj-art-b8f02a0045014a1bb6cb92a6b8717763 |
| institution | DOAJ |
| issn | 1411-9420 2460-1578 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj-art-b8f02a0045014a1bb6cb92a6b87177632025-08-20T02:50:45ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782024-12-012461811182310.22146/ijc.9716036527Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin DeliveryZainab Jasim Khudair0Zeina Mohammad Kadam1Department of Science, College of Basic Education, Al-Muthanna University, Al-Qishla, Samawah 66001, IraqDepartment of Chemistry, College of Science, Al-Qadisiyah University, Um-Alkhail, Diwaniyah 58001, IraqThe present study involved the synthesis of a bioactive composite material using chitosan (CS) and multi-walled carbon nanotubes (MWCNTs) through the free radical polymerization method. The resulting composite material was comprehensively characterized using various experimental techniques, such as Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The quantification of the swelling behavior involved the measurement of changes in the weight of the sample as a function of the time it was immersed in an aqueous buffered solution. The findings indicated that the maximum drug-loading rate of ofloxacin medication (OFL) was 86%. Moreover, the pH sensitivity of the poly acrylic acid grafting multi-walled carbon nanotubes p(CS-co-AA)/MWCNTs nanocomposite facilitated the substantial release of a significant quantity of medication in aqueous buffered solution at a pH of 1.2. The average rate of drug release was measured to be 76% after 72 h duration. On the other hand, the release of the drug at pH 5 and 7.4 was 42% and 32%, respectively. According to the reported findings, the p(CS-co-AA)/MWCNTs carrier has a favorable capacity to control the release of the OFL drug into the intended medium while reducing potential negative effects.https://jurnal.ugm.ac.id/ijc/article/view/97160mwcntofloxacin drugdrug loadingswelling ratioin vitro release |
| spellingShingle | Zainab Jasim Khudair Zeina Mohammad Kadam Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin Delivery Indonesian Journal of Chemistry mwcnt ofloxacin drug drug loading swelling ratio in vitro release |
| title | Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin Delivery |
| title_full | Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin Delivery |
| title_fullStr | Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin Delivery |
| title_full_unstemmed | Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin Delivery |
| title_short | Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin Delivery |
| title_sort | physicochemical characterization of chitosan multiwalled carbon nanotubes hybrid material for ofloxacin delivery |
| topic | mwcnt ofloxacin drug drug loading swelling ratio in vitro release |
| url | https://jurnal.ugm.ac.id/ijc/article/view/97160 |
| work_keys_str_mv | AT zainabjasimkhudair physicochemicalcharacterizationofchitosanmultiwalledcarbonnanotubeshybridmaterialforofloxacindelivery AT zeinamohammadkadam physicochemicalcharacterizationofchitosanmultiwalledcarbonnanotubeshybridmaterialforofloxacindelivery |