Physicochemical Characterization of Chitosan-Multiwalled Carbon Nanotubes Hybrid Material for Ofloxacin Delivery
The present study involved the synthesis of a bioactive composite material using chitosan (CS) and multi-walled carbon nanotubes (MWCNTs) through the free radical polymerization method. The resulting composite material was comprehensively characterized using various experimental techniques, such as...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Department of Chemistry, Universitas Gadjah Mada
2024-12-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/97160 |
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| Summary: | The present study involved the synthesis of a bioactive composite material using chitosan (CS) and multi-walled carbon nanotubes (MWCNTs) through the free radical polymerization method. The resulting composite material was comprehensively characterized using various experimental techniques, such as Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The quantification of the swelling behavior involved the measurement of changes in the weight of the sample as a function of the time it was immersed in an aqueous buffered solution. The findings indicated that the maximum drug-loading rate of ofloxacin medication (OFL) was 86%. Moreover, the pH sensitivity of the poly acrylic acid grafting multi-walled carbon nanotubes p(CS-co-AA)/MWCNTs nanocomposite facilitated the substantial release of a significant quantity of medication in aqueous buffered solution at a pH of 1.2. The average rate of drug release was measured to be 76% after 72 h duration. On the other hand, the release of the drug at pH 5 and 7.4 was 42% and 32%, respectively. According to the reported findings, the p(CS-co-AA)/MWCNTs carrier has a favorable capacity to control the release of the OFL drug into the intended medium while reducing potential negative effects. |
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| ISSN: | 1411-9420 2460-1578 |