The impact of cyclin D1 on endometrial hyperplasia and endometrioid endometrial carcinoma
Introduction: Endometrioid endometrial carcinoma (EEC) is the most common type of endometrial cancer, accounting for approximately 80-90% of all endometrial cancer cases. Endometrial hyperplasia deserves special attention because of its relationship with endometrialcinoma. This study's goal was...
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KIMS Foundation and Research Center
2025-06-01
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| Online Access: | https://jmsronline.com/archive-article/cyclin-D1-endometrial-hyperplasia-carcinoma |
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| author | Sudha M Shanmugapriya M Vijay A |
| author_facet | Sudha M Shanmugapriya M Vijay A |
| author_sort | Sudha M |
| collection | DOAJ |
| description | Introduction: Endometrioid endometrial carcinoma (EEC) is the most common type of endometrial cancer, accounting for approximately 80-90% of all endometrial cancer cases. Endometrial hyperplasia deserves special attention because of its relationship with endometrialcinoma. This study's goal was to use immunohistochemistry to investigate the expression of cyclin D1 between hyperplasia without atypia, atypical hyperplasia and endometrioid endometrial carcinoma.
Methods: We evaluated and compared the expression of cyclin D1 in 15 endometrial samples, including 5 cases of hyperplasia without atypia, cases of atypical hyperplasia, and another 5 cases of endometrioid endometrial carcinoma.
Results: In our study results, cyclin D1 was considerably overexpressed in glands with endometrioid endometrial carcinoma compared to atypical hyperplasia and hyperplasia without atypia. Our investigation demonstrated a statistically significant relationship between diagnostic type and cyclin D1 expression levels (p-value = 0.034).
Conclusion: The current work demonstrates that cyclin D1 overexpression may be a useful biomarker for identifying subsets of endometrial lesions that are precancerous and hence amenable to surgical treatment. Cyclin D1 is a critical regulator of cell cycle progression and plays a significant role in the development and progression of endometrial carcinoma. Further research is needed to fully elucidate the mechanisms of cyclin D1 regulation and to develop novel therapeutic strategies targeting cyclin D1 and its regulatory mechanisms.
Keywords: cyclin D1; endometrioid endometrial carcinoma; endometrial hyperplasia; atypical hyperplasia; immunohistochemistry |
| format | Article |
| id | doaj-art-b8eaee6838a34f2bb602399359e6fd96 |
| institution | Kabale University |
| issn | 2321-1326 2394-112X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | KIMS Foundation and Research Center |
| record_format | Article |
| series | Journal of Medical and Scientific Research |
| spelling | doaj-art-b8eaee6838a34f2bb602399359e6fd962025-08-20T03:30:15ZengKIMS Foundation and Research CenterJournal of Medical and Scientific Research2321-13262394-112X2025-06-011329095http://dx.doi.org/10.17727/JMSR.2024/13-16The impact of cyclin D1 on endometrial hyperplasia and endometrioid endometrial carcinomaSudha M0Shanmugapriya M1Vijay A2Department of Pathology, ACS Medical College and Hospital, Tamil Nadu 600077, IndiaDepartment of Pathology, Meenakshi Medical College Hospital and Research Institute, Enathur, Tamil Nadu 631552, IndiaDepartment of Pathology, St Peter's Medical College Hospital and Research Institute, Hosur, Krishnagiri District, Tamil Nadu 635130, IndiaIntroduction: Endometrioid endometrial carcinoma (EEC) is the most common type of endometrial cancer, accounting for approximately 80-90% of all endometrial cancer cases. Endometrial hyperplasia deserves special attention because of its relationship with endometrialcinoma. This study's goal was to use immunohistochemistry to investigate the expression of cyclin D1 between hyperplasia without atypia, atypical hyperplasia and endometrioid endometrial carcinoma. Methods: We evaluated and compared the expression of cyclin D1 in 15 endometrial samples, including 5 cases of hyperplasia without atypia, cases of atypical hyperplasia, and another 5 cases of endometrioid endometrial carcinoma. Results: In our study results, cyclin D1 was considerably overexpressed in glands with endometrioid endometrial carcinoma compared to atypical hyperplasia and hyperplasia without atypia. Our investigation demonstrated a statistically significant relationship between diagnostic type and cyclin D1 expression levels (p-value = 0.034). Conclusion: The current work demonstrates that cyclin D1 overexpression may be a useful biomarker for identifying subsets of endometrial lesions that are precancerous and hence amenable to surgical treatment. Cyclin D1 is a critical regulator of cell cycle progression and plays a significant role in the development and progression of endometrial carcinoma. Further research is needed to fully elucidate the mechanisms of cyclin D1 regulation and to develop novel therapeutic strategies targeting cyclin D1 and its regulatory mechanisms. Keywords: cyclin D1; endometrioid endometrial carcinoma; endometrial hyperplasia; atypical hyperplasia; immunohistochemistryhttps://jmsronline.com/archive-article/cyclin-D1-endometrial-hyperplasia-carcinomacyclin d1endometrioid endometrial carcinomaendometrial hyperplasiaatypical hyperplasia |
| spellingShingle | Sudha M Shanmugapriya M Vijay A The impact of cyclin D1 on endometrial hyperplasia and endometrioid endometrial carcinoma Journal of Medical and Scientific Research cyclin d1 endometrioid endometrial carcinoma endometrial hyperplasia atypical hyperplasia |
| title | The impact of cyclin D1 on endometrial hyperplasia and endometrioid endometrial carcinoma |
| title_full | The impact of cyclin D1 on endometrial hyperplasia and endometrioid endometrial carcinoma |
| title_fullStr | The impact of cyclin D1 on endometrial hyperplasia and endometrioid endometrial carcinoma |
| title_full_unstemmed | The impact of cyclin D1 on endometrial hyperplasia and endometrioid endometrial carcinoma |
| title_short | The impact of cyclin D1 on endometrial hyperplasia and endometrioid endometrial carcinoma |
| title_sort | impact of cyclin d1 on endometrial hyperplasia and endometrioid endometrial carcinoma |
| topic | cyclin d1 endometrioid endometrial carcinoma endometrial hyperplasia atypical hyperplasia |
| url | https://jmsronline.com/archive-article/cyclin-D1-endometrial-hyperplasia-carcinoma |
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