A data-mining analysis of host solute carrier family proteins in SARS-CoV-2 infection with reference to brain endothelial cells and the blood-brain barrier in COVID-19

A data-mining analysis of host solute carrier family proteins in SARS-CoV-2 infection with reference to brain endothelial cells and the blood-brain barrier in COVID-19

BackgroundThe brain vasculature is a key player in neurological manifestations of COVID-19. Infection of brain endothelial cells with SARS-CoV-2 along with circulating cytokines may cause dysfunction of the blood-brain barrier (BBB). Solute carrier transporters (SLCs) in brain endothelial cells regu...

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Bibliographic Details
Main Authors: Talia Fradkin, Rainald Schmidt-Kastner
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neurology
Subjects:
SARS-CoV-2
COVID-19
blood-brain barrier
brain endothelial cells
solute carrier proteins
amino acid transport
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1563040/full
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