Mitochondria-targeted therapy with metformin and MitoQ reduces oxidative stress, improves mitochondrial function, and restores metabolic homeostasis in a murine model of Gulf War Illness

Mitochondria-targeted therapy with metformin and MitoQ reduces oxidative stress, improves mitochondrial function, and restores metabolic homeostasis in a murine model of Gulf War Illness

Gulf War Illness (GWI) is a cluster of medically unexplained chronic symptoms, including neurological and gastrointestinal impairments, and muscle fatigue, suffered by veterans of the Persian Gulf War. A GWI model in C57BL/6 mice exposed to the nerve gas prophylactic pyridostigmine-bromide (PB) and...

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Bibliographic Details
Main Authors: Lun Cai, Mundanattu Swetha, Abraham Raji, Alvin V. Terry, Jr., Raghavan Pillai Raju
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Gulf War Illness
Metformin
MitoQ
AMPK
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002277
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