Acute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentation
Abstract Background While vaccination remains crucial in mitigating the impact of the COVID-19 pandemic, several ocular adverse events has been reported, including Acute Zonal Occult Outer Retinopathy (AZOOR) complex. Case presentation A 31-year-old female presented declined best corrected visual ac...
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BMC
2025-01-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-03844-z |
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| author | Nai-Wen Chang Chia-hao Kuo Hung-Da Chou Yi-Hsing Chen |
| author_facet | Nai-Wen Chang Chia-hao Kuo Hung-Da Chou Yi-Hsing Chen |
| author_sort | Nai-Wen Chang |
| collection | DOAJ |
| description | Abstract Background While vaccination remains crucial in mitigating the impact of the COVID-19 pandemic, several ocular adverse events has been reported, including Acute Zonal Occult Outer Retinopathy (AZOOR) complex. Case presentation A 31-year-old female presented declined best corrected visual acuity (BCVA) and flashes in both eyes three days following second recombinant mRNA COVID-19 vaccine (Moderna). Fundus autofluorescence (FAF) illustrated speckled hyper-AF lesions surrounding right eye torpedo maculopathy site and hyper-AF lesions in the left macula. The spectral-domain optical coherence tomography delineated inner and outer segment (IS/OS) line disruption; hyperreflective deposits in the outer nuclear layer (ONL); and undetectable interdigitation zone (IDZ). Her BCVA further declined after 3-month observation, thus she received 8-month oral prednisolone and mycophenolate mofetil treatment. Her BCVA recovered; the hype-AF lesions resolved; and the IS/OS line and ONL resumed. Conclusions We present a rare case of AZOOR complex following COVID-19 vaccination inciting from torpedo retinopathy where outer-retinal barrier breaks down. |
| format | Article |
| id | doaj-art-b8e7ec8960f1422a8e8ed33321c3dc7c |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-b8e7ec8960f1422a8e8ed33321c3dc7c2025-01-19T12:14:30ZengBMCBMC Ophthalmology1471-24152025-01-012511610.1186/s12886-025-03844-zAcute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentationNai-Wen Chang0Chia-hao Kuo1Hung-Da Chou2Yi-Hsing Chen3Department of Medical Education, Linkou main branch, Chang Gung Memorial HospitalDepartment of Ophthalmology, Kaohsiung Veterans General HospitalDepartment of Ophthalmology, Linkou main branch, Chang Gung Memorial HospitalDepartment of Ophthalmology, Linkou main branch, Chang Gung Memorial HospitalAbstract Background While vaccination remains crucial in mitigating the impact of the COVID-19 pandemic, several ocular adverse events has been reported, including Acute Zonal Occult Outer Retinopathy (AZOOR) complex. Case presentation A 31-year-old female presented declined best corrected visual acuity (BCVA) and flashes in both eyes three days following second recombinant mRNA COVID-19 vaccine (Moderna). Fundus autofluorescence (FAF) illustrated speckled hyper-AF lesions surrounding right eye torpedo maculopathy site and hyper-AF lesions in the left macula. The spectral-domain optical coherence tomography delineated inner and outer segment (IS/OS) line disruption; hyperreflective deposits in the outer nuclear layer (ONL); and undetectable interdigitation zone (IDZ). Her BCVA further declined after 3-month observation, thus she received 8-month oral prednisolone and mycophenolate mofetil treatment. Her BCVA recovered; the hype-AF lesions resolved; and the IS/OS line and ONL resumed. Conclusions We present a rare case of AZOOR complex following COVID-19 vaccination inciting from torpedo retinopathy where outer-retinal barrier breaks down.https://doi.org/10.1186/s12886-025-03844-zTorpedo retinopathyAcute zonal occult outer retinopathy (AZOOR)Recombinant mRNA vaccine |
| spellingShingle | Nai-Wen Chang Chia-hao Kuo Hung-Da Chou Yi-Hsing Chen Acute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentation BMC Ophthalmology Torpedo retinopathy Acute zonal occult outer retinopathy (AZOOR) Recombinant mRNA vaccine |
| title | Acute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentation |
| title_full | Acute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentation |
| title_fullStr | Acute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentation |
| title_full_unstemmed | Acute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentation |
| title_short | Acute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentation |
| title_sort | acute zonal occult outer retinopathy azoor complex associated with torpedo retinopathy following covid 19 recombinant mrna vaccination a case report of a rare clinical presentation |
| topic | Torpedo retinopathy Acute zonal occult outer retinopathy (AZOOR) Recombinant mRNA vaccine |
| url | https://doi.org/10.1186/s12886-025-03844-z |
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