Association between the p53 polymorphisms and cervical cancer risk: an updated meta-analysis
BackgroundThe association of the p53 rs1042522 and rs17878362 polymorphisms with cervical cancer risk has been reported in several published original studies and meta-analyses. However, the conclusions of these studies were contradictory. Consequently, we conducted an updated meta-analysis to furthe...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1461737/full |
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| author | Xi-Qin Zhang Xiao-Hui Bai Hui-Zhen Zhang Xiao-Feng He |
| author_facet | Xi-Qin Zhang Xiao-Hui Bai Hui-Zhen Zhang Xiao-Feng He |
| author_sort | Xi-Qin Zhang |
| collection | DOAJ |
| description | BackgroundThe association of the p53 rs1042522 and rs17878362 polymorphisms with cervical cancer risk has been reported in several published original studies and meta-analyses. However, the conclusions of these studies were contradictory. Consequently, we conducted an updated meta-analysis to further validate these debates.ObjectiveTo evaluate the association between the p53 rs1042522 and rs17878362 polymorphisms and cervical cancer risk.Materials and MethodsPubMed, Medline, Ovid, Embase, CNKI, and China Wanfang databases were searched. Association was assessed using odds ratio (OR) with 95% confidence interval (CI). Moreover, the false-positive reporting probability (FPRP), Bayesian false-finding probability (BFDP), and Venice criteria were used to assess the credibility of statistically significant association.ResultsA significantly decreased cervical cancer risk was revealed for the p53 rs1042522 polymorphism (Pro/Pro +Arg/Pro vs. Arg/Arg: OR = 0.79, 95% CI = 0.71-0.87; Pro/Pro vs. Arg/Arg: OR = 0.80, 95% CI = 0.70-0.91; Arg/Pro vs. Arg/Arg: OR = 0.78, 95% CI = 0.71-0.86; Pro vs. Arg: OR = 0.87, 95% CI = 0.81-0.93) in overall analysis and several subgroup analyses, such as in Caucasians, Asians, Indians, and so on. However, no significant association was found between the p53 rs17878362 polymorphism and cervical cancer risk. Despite these statistically significant results, reliability analysis using FPRP, BFDP, and Venice criteria deemed all associations “unreliable”.ConclusionsAfter considering the reliability of the results, this study indicates that the p53 rs1042522 polymorphism is not associated with the cervical cancer risk. |
| format | Article |
| id | doaj-art-b8e77acc58604b1a8cc350805b5cf4e0 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-b8e77acc58604b1a8cc350805b5cf4e02025-08-20T03:11:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14617371461737Association between the p53 polymorphisms and cervical cancer risk: an updated meta-analysisXi-Qin Zhang0Xiao-Hui Bai1Hui-Zhen Zhang2Xiao-Feng He3Department of Gynaecology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, ChinaGuilin Medical University, Guilin, Guangxi, ChinaDepartment of Gynaecology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, ChinaInstitute of Evidence-Based Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, ChinaBackgroundThe association of the p53 rs1042522 and rs17878362 polymorphisms with cervical cancer risk has been reported in several published original studies and meta-analyses. However, the conclusions of these studies were contradictory. Consequently, we conducted an updated meta-analysis to further validate these debates.ObjectiveTo evaluate the association between the p53 rs1042522 and rs17878362 polymorphisms and cervical cancer risk.Materials and MethodsPubMed, Medline, Ovid, Embase, CNKI, and China Wanfang databases were searched. Association was assessed using odds ratio (OR) with 95% confidence interval (CI). Moreover, the false-positive reporting probability (FPRP), Bayesian false-finding probability (BFDP), and Venice criteria were used to assess the credibility of statistically significant association.ResultsA significantly decreased cervical cancer risk was revealed for the p53 rs1042522 polymorphism (Pro/Pro +Arg/Pro vs. Arg/Arg: OR = 0.79, 95% CI = 0.71-0.87; Pro/Pro vs. Arg/Arg: OR = 0.80, 95% CI = 0.70-0.91; Arg/Pro vs. Arg/Arg: OR = 0.78, 95% CI = 0.71-0.86; Pro vs. Arg: OR = 0.87, 95% CI = 0.81-0.93) in overall analysis and several subgroup analyses, such as in Caucasians, Asians, Indians, and so on. However, no significant association was found between the p53 rs17878362 polymorphism and cervical cancer risk. Despite these statistically significant results, reliability analysis using FPRP, BFDP, and Venice criteria deemed all associations “unreliable”.ConclusionsAfter considering the reliability of the results, this study indicates that the p53 rs1042522 polymorphism is not associated with the cervical cancer risk.https://www.frontiersin.org/articles/10.3389/fonc.2025.1461737/fullp53polymorphismriskcervical cancermeta-analysis |
| spellingShingle | Xi-Qin Zhang Xiao-Hui Bai Hui-Zhen Zhang Xiao-Feng He Association between the p53 polymorphisms and cervical cancer risk: an updated meta-analysis Frontiers in Oncology p53 polymorphism risk cervical cancer meta-analysis |
| title | Association between the p53 polymorphisms and cervical cancer risk: an updated meta-analysis |
| title_full | Association between the p53 polymorphisms and cervical cancer risk: an updated meta-analysis |
| title_fullStr | Association between the p53 polymorphisms and cervical cancer risk: an updated meta-analysis |
| title_full_unstemmed | Association between the p53 polymorphisms and cervical cancer risk: an updated meta-analysis |
| title_short | Association between the p53 polymorphisms and cervical cancer risk: an updated meta-analysis |
| title_sort | association between the p53 polymorphisms and cervical cancer risk an updated meta analysis |
| topic | p53 polymorphism risk cervical cancer meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1461737/full |
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