Immunomodulatory effects of Eimeria maxima surface antigen (EmSAG) as an IFN-γ inhibitory molecule on peripheral blood mononuclear cells (PBMCs) and T cell subsets in chickens

Immunomodulatory effects of Eimeria maxima surface antigen (EmSAG) as an IFN-γ inhibitory molecule on peripheral blood mononuclear cells (PBMCs) and T cell subsets in chickens

Abstract Eimeria maxima (E. maxima) infection inhibits the expression of IFN-γ, a cytokine that is essential for the Th1 immune response and plays a key role in combating this parasite. In our preliminary investigations, we identified the E. maxima surface antigen (EmSAG) as an inhibitory molecule o...

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Bibliographic Details
Main Authors: Xianglin Pu, Yiyuan Zhang, Xinmei Huang, Mingmin Lu, Lixin Xu, Ruofeng Yan, Xiangrui Li, Xiaokai Song
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Veterinary Research
Subjects:
IFN-γ inhibitory molecule
EmSAG
T cell subsets
immune evasion
immunomodulation
Online Access:https://doi.org/10.1186/s13567-025-01535-7
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https://doi.org/10.1186/s13567-025-01535-7

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