Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II
Reactive oxygen species are oxygen derivates and play an active role in vascular biology. These compounds are generated within the vascular wall, at the level of endothelial and vascular smooth muscle cells, as well as by adventitial fibroblasts. In healthy conditions, ROS are produced in a controll...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/916310 |
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| _version_ | 1849686129154981888 |
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| author | Agostino Virdis Emiliano Duranti Stefano Taddei |
| author_facet | Agostino Virdis Emiliano Duranti Stefano Taddei |
| author_sort | Agostino Virdis |
| collection | DOAJ |
| description | Reactive oxygen species are oxygen derivates and play an active role in vascular biology. These compounds are generated within the vascular wall, at the level of endothelial and vascular smooth muscle cells, as well as by adventitial fibroblasts. In healthy conditions, ROS are produced in a controlled manner at low concentrations and function as signaling molecules regulating vascular contraction-relaxation and cell growth. Physiologically, the rate of ROS generation is counterbalanced by the rate of elimination. In hypertension, an enhanced ROS generation occurs, which is not counterbalanced by the endogenous antioxidant mechanisms, leading to a state of oxidative stress. In the present paper, major angiotensin II-induced vascular ROS generation within the vasculature, and relative sources, will be discussed. Recent development of signalling pathways whereby angiotensin II-driven vascular ROS induce and accelerate functional and structural vascular injury will be also considered. |
| format | Article |
| id | doaj-art-b8d6d5664fc240e1a8b26d99e341e270 |
| institution | DOAJ |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-b8d6d5664fc240e1a8b26d99e341e2702025-08-20T03:22:49ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/916310916310Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin IIAgostino Virdis0Emiliano Duranti1Stefano Taddei2Department of Internal Medicine, University of Pisa, 56100 Pisa, ItalyDepartment of Internal Medicine, University of Pisa, 56100 Pisa, ItalyDepartment of Internal Medicine, University of Pisa, 56100 Pisa, ItalyReactive oxygen species are oxygen derivates and play an active role in vascular biology. These compounds are generated within the vascular wall, at the level of endothelial and vascular smooth muscle cells, as well as by adventitial fibroblasts. In healthy conditions, ROS are produced in a controlled manner at low concentrations and function as signaling molecules regulating vascular contraction-relaxation and cell growth. Physiologically, the rate of ROS generation is counterbalanced by the rate of elimination. In hypertension, an enhanced ROS generation occurs, which is not counterbalanced by the endogenous antioxidant mechanisms, leading to a state of oxidative stress. In the present paper, major angiotensin II-induced vascular ROS generation within the vasculature, and relative sources, will be discussed. Recent development of signalling pathways whereby angiotensin II-driven vascular ROS induce and accelerate functional and structural vascular injury will be also considered.http://dx.doi.org/10.4061/2011/916310 |
| spellingShingle | Agostino Virdis Emiliano Duranti Stefano Taddei Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II International Journal of Hypertension |
| title | Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II |
| title_full | Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II |
| title_fullStr | Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II |
| title_full_unstemmed | Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II |
| title_short | Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II |
| title_sort | oxidative stress and vascular damage in hypertension role of angiotensin ii |
| url | http://dx.doi.org/10.4061/2011/916310 |
| work_keys_str_mv | AT agostinovirdis oxidativestressandvasculardamageinhypertensionroleofangiotensinii AT emilianoduranti oxidativestressandvasculardamageinhypertensionroleofangiotensinii AT stefanotaddei oxidativestressandvasculardamageinhypertensionroleofangiotensinii |