Gen inhibiting the Wnt/Ca2+ signaling pathway alleviates cerebral ischemia/reperfusion injury

Gen inhibiting the Wnt/Ca2+ signaling pathway alleviates cerebral ischemia/reperfusion injury

Abstract Cerebral ischemia/reperfusion injury (CIRI) is a major complication of acute ischemic stroke (AIS), characterized by calcium overload, oxidative stress, and cell apoptosis. In this study, we investigated the therapeutic potential of Genistein (Gen) in alleviating CIRI by focusing on its eff...

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Bibliographic Details
Main Authors: Li Li, Saisai Liu, Mengzhe Wang, Mengjia Li, Yi Liu, Haili Chen, Jie Chen, Weiting Tao, Li Huang, Shidi Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
CIRI
Gen
Wnt/Ca2+
Calcium overload
Online Access:https://doi.org/10.1038/s41598-025-88136-8
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