Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data
BackgroundOsteoarthritis (OA) is characterized by high morbidity and disability. While studies have demonstrated that OA is correlated with age-related diseases, few have shown the potential relationship between OA and obstructive sleep apnea syndrome (OSAS). OSAS is characterized by intermittent hy...
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Frontiers Media S.A.
2024-11-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1486807/full |
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| author | Xin Luo Minghong Chen Jinghong Xu |
| author_facet | Xin Luo Minghong Chen Jinghong Xu |
| author_sort | Xin Luo |
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| description | BackgroundOsteoarthritis (OA) is characterized by high morbidity and disability. While studies have demonstrated that OA is correlated with age-related diseases, few have shown the potential relationship between OA and obstructive sleep apnea syndrome (OSAS). OSAS is characterized by intermittent hypoxia and hypercapnia. We hypothesize that these stressors induce aging and increase the prevalence of OA.MethodsThe study included 10,641 participants drawn from the National Health and Nutrition Examination Survey (NHANES) dataset during 2005–2008 and 2015–2018. The correlation between OSAS and OA was analyzed using multivariable logistic regression, aging-related biomarkers were calculated, and the role of aging was explored through mediation analysis.ResultsOSAS was associated with an elevated risk of OA (for quartile 4 vs. quartile 1, odds ratio (OR) 2.31, 95% confidence interval (CI) 1.34 to 3.99; p-value for the trend = 0.004) after adjusting covariates. In the 20–59 years and > 60 years subgroup, the OSAS patients showed a similar trend (for quartile 4 vs. quartile 1, OR 5.69, 95% CI 2.75 to 11.8; p-value for the trend <0.001; OR 2.42, 95% CI 1.23 to 4.76; p-value for the trend = 0.004, respectively). Further mediation analysis revealed that aging acted as a mediator between OA and OSAS. The mediation proportions for biological age (BA) and phenotypic age (PA) were 13.82 and 52.94%, respectively, both with p < 0.001.ConclusionThese findings suggest that individuals with OSAS may have an increased prevalence of OA, with aging also being involved in the association. |
| format | Article |
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| institution | OA Journals |
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| language | English |
| publishDate | 2024-11-01 |
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| series | Frontiers in Medicine |
| spelling | doaj-art-b8c64fc471aa49f296e70883ef69468a2025-08-20T02:27:42ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-11-011110.3389/fmed.2024.14868071486807Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES dataXin Luo0Minghong Chen1Jinghong Xu2Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Trauma Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, ChinaBackgroundOsteoarthritis (OA) is characterized by high morbidity and disability. While studies have demonstrated that OA is correlated with age-related diseases, few have shown the potential relationship between OA and obstructive sleep apnea syndrome (OSAS). OSAS is characterized by intermittent hypoxia and hypercapnia. We hypothesize that these stressors induce aging and increase the prevalence of OA.MethodsThe study included 10,641 participants drawn from the National Health and Nutrition Examination Survey (NHANES) dataset during 2005–2008 and 2015–2018. The correlation between OSAS and OA was analyzed using multivariable logistic regression, aging-related biomarkers were calculated, and the role of aging was explored through mediation analysis.ResultsOSAS was associated with an elevated risk of OA (for quartile 4 vs. quartile 1, odds ratio (OR) 2.31, 95% confidence interval (CI) 1.34 to 3.99; p-value for the trend = 0.004) after adjusting covariates. In the 20–59 years and > 60 years subgroup, the OSAS patients showed a similar trend (for quartile 4 vs. quartile 1, OR 5.69, 95% CI 2.75 to 11.8; p-value for the trend <0.001; OR 2.42, 95% CI 1.23 to 4.76; p-value for the trend = 0.004, respectively). Further mediation analysis revealed that aging acted as a mediator between OA and OSAS. The mediation proportions for biological age (BA) and phenotypic age (PA) were 13.82 and 52.94%, respectively, both with p < 0.001.ConclusionThese findings suggest that individuals with OSAS may have an increased prevalence of OA, with aging also being involved in the association.https://www.frontiersin.org/articles/10.3389/fmed.2024.1486807/fullagingNHANESosteoarthritisobstructive sleep apnea syndromemediation analysis |
| spellingShingle | Xin Luo Minghong Chen Jinghong Xu Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data Frontiers in Medicine aging NHANES osteoarthritis obstructive sleep apnea syndrome mediation analysis |
| title | Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data |
| title_full | Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data |
| title_fullStr | Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data |
| title_full_unstemmed | Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data |
| title_short | Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data |
| title_sort | exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis insights from nhanes data |
| topic | aging NHANES osteoarthritis obstructive sleep apnea syndrome mediation analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1486807/full |
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