Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study
Objective The Visceral Adiposity Index (VAI) is a marker of visceral fat accumulation and dysfunction. We aimed to investigate the association between VAI and incident colorectal cancer (CRC).Design In this historical cohort study of 27 921 (16 434 men and 11 487 women) participants, we divided the...
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BMJ Publishing Group
2020-12-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/7/1/e000400.full |
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| author | Michiaki Fukui Masahide Hamaguchi Yoshitaka Hashimoto Akihiro Obora Takao Kojima Takuro Okamura |
| author_facet | Michiaki Fukui Masahide Hamaguchi Yoshitaka Hashimoto Akihiro Obora Takao Kojima Takuro Okamura |
| author_sort | Michiaki Fukui |
| collection | DOAJ |
| description | Objective The Visceral Adiposity Index (VAI) is a marker of visceral fat accumulation and dysfunction. We aimed to investigate the association between VAI and incident colorectal cancer (CRC).Design In this historical cohort study of 27 921 (16 434 men and 11 487 women) participants, we divided the participants into tertiles according to VAI. We calculated VAI: men, VAI = (waist circumference (WC)/(39.68+1.88 × body mass index (BMI))) × (triglycerides (TG)/1.03) × (1.31/high-density lipoprotein cholesterol (HDL)); women, VAI = (WC/(36.58+1.89 × BMI)) × (TG/0.81) × (1.52/HDL). We performed Cox proportional hazard models, adjusting for sex, age, smoking, alcohol consumption, exercise, haemoglobin A1c and systolic blood pressure.Results During the median 4.4-year follow-up, 116 participants developed CRC. Compared with the lowest tertile, the HRs of incident CRC in the middle and the highest tertiles were 1.30 (95% CI 0.76 to 2.28, p=0.338) and 2.41 (1.50 to 4.02, p<0.001) in univariate analysis. Moreover, the HRs of incident CRC in the middle and the highest tertiles were 1.27 (0.73 to 2.23, p=0.396) and 1.98 (1.15 to 3.39, p=0.013) after adjusting for covariates.Conclusions VAI can be a predictor of incident CRC. For early detection, we should encourage people with high VAI to undergo screening for CRC. |
| format | Article |
| id | doaj-art-b8c64ae89e44491d8f854ce44977f372 |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-b8c64ae89e44491d8f854ce44977f3722024-12-14T15:25:07ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742020-12-017110.1136/bmjgast-2020-000400Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal studyMichiaki Fukui0Masahide Hamaguchi1Yoshitaka Hashimoto2Akihiro Obora3Takao Kojima4Takuro Okamura5Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Kyoto, JapanEndocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanDepartment of Gastroenterology, Asahi University Hospital, Gifu, JapanDepartment of Gastroenterology, Asahi University Hospital, Gifu, JapanDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanObjective The Visceral Adiposity Index (VAI) is a marker of visceral fat accumulation and dysfunction. We aimed to investigate the association between VAI and incident colorectal cancer (CRC).Design In this historical cohort study of 27 921 (16 434 men and 11 487 women) participants, we divided the participants into tertiles according to VAI. We calculated VAI: men, VAI = (waist circumference (WC)/(39.68+1.88 × body mass index (BMI))) × (triglycerides (TG)/1.03) × (1.31/high-density lipoprotein cholesterol (HDL)); women, VAI = (WC/(36.58+1.89 × BMI)) × (TG/0.81) × (1.52/HDL). We performed Cox proportional hazard models, adjusting for sex, age, smoking, alcohol consumption, exercise, haemoglobin A1c and systolic blood pressure.Results During the median 4.4-year follow-up, 116 participants developed CRC. Compared with the lowest tertile, the HRs of incident CRC in the middle and the highest tertiles were 1.30 (95% CI 0.76 to 2.28, p=0.338) and 2.41 (1.50 to 4.02, p<0.001) in univariate analysis. Moreover, the HRs of incident CRC in the middle and the highest tertiles were 1.27 (0.73 to 2.23, p=0.396) and 1.98 (1.15 to 3.39, p=0.013) after adjusting for covariates.Conclusions VAI can be a predictor of incident CRC. For early detection, we should encourage people with high VAI to undergo screening for CRC.https://bmjopengastro.bmj.com/content/7/1/e000400.full |
| spellingShingle | Michiaki Fukui Masahide Hamaguchi Yoshitaka Hashimoto Akihiro Obora Takao Kojima Takuro Okamura Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study BMJ Open Gastroenterology |
| title | Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_full | Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_fullStr | Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_full_unstemmed | Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_short | Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_sort | visceral adiposity index is a predictor of incident colorectal cancer a population based longitudinal study |
| url | https://bmjopengastro.bmj.com/content/7/1/e000400.full |
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