Genetic Polymorphisms of the Vitamin D Receptor ApaI Gene and Physiological Parameters Diversity of Polycystic Ovary Syndrome in Iraqi Women
Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder among women of reproductive age, requiring diverse management strategies. This study, conducted at Kamal Al-Samarrai Hospital Fertility Center/Baghdad from January to March 2023, included 80 Iraqi women aged 18-45, comprising 40 with...
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Corporation of Research and Industrial Development
2024-06-01
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| Series: | Iraqi Journal of Industrial Research |
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| Online Access: | http://ijoir.gov.iq/ijoir/index.php/jou/article/view/418 |
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| author | Safa F. Ali Shiva Khezri Ilham A. Khalaf Dalia J. Mahmood |
| author_facet | Safa F. Ali Shiva Khezri Ilham A. Khalaf Dalia J. Mahmood |
| author_sort | Safa F. Ali |
| collection | DOAJ |
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Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder among women of reproductive age, requiring diverse management strategies. This study, conducted at Kamal Al-Samarrai Hospital Fertility Center/Baghdad from January to March 2023, included 80 Iraqi women aged 18-45, comprising 40 with PCOS and 40 healthy controls. Hormonal markers (FSH, LH, T, PRL, Ca2+, and Vitamin D3) were systematically assessed, along with Apa1 gene polymorphisms in whole blood genomic DNA using PCR-RFLP. PCOS patients showed significantly elevated LH, LH/FSH, T, and PRL levels (p < 0.01) and lower Vitamin D and calcium levels (p < 0.05) compared to controls. The scrutiny of VDR gene Apa1 polymorphism uncovered a notable prevalence of "Aa" and "aa" genotypes among PCOS patients, constituting 65.00% and 25.00%, respectively, in contrast to the control group's 17.50% and 0.00% in controls. The "aa" allele, more frequent in PCOS, emerged as a potential risk factor for the condition. This study establishes a strong association between VDR gene (Apa1) polymorphism and PCOS, highlighting the significance of the "aa" allele. It emphasizes the homozygous variant genotype "aa" as a substantial risk factor for PCOS, providing insights into its genetic basis.
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| format | Article |
| id | doaj-art-b8bdd4b5a66a413896b50cfada5bd76f |
| institution | DOAJ |
| issn | 2788-712X |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Corporation of Research and Industrial Development |
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| series | Iraqi Journal of Industrial Research |
| spelling | doaj-art-b8bdd4b5a66a413896b50cfada5bd76f2025-08-20T02:39:13ZengCorporation of Research and Industrial DevelopmentIraqi Journal of Industrial Research2788-712X2024-06-0111110.53523/ijoirVol11I1ID418418Genetic Polymorphisms of the Vitamin D Receptor ApaI Gene and Physiological Parameters Diversity of Polycystic Ovary Syndrome in Iraqi WomenSafa F. Ali0Shiva Khezri1Ilham A. Khalaf2Dalia J. Mahmood3Al-Razi Center for Research and Diagnostic Kit Production/ Corporation of Research and Industrial Development, IraqDepartment of Biology, Faculty of Science, Urmia University, IranAl-Razi Center for Research and Diagnostic Kit Production/ Corporation of Research and Industrial Development, IraqKamal Al-Samarrai Hospital, Iraq Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder among women of reproductive age, requiring diverse management strategies. This study, conducted at Kamal Al-Samarrai Hospital Fertility Center/Baghdad from January to March 2023, included 80 Iraqi women aged 18-45, comprising 40 with PCOS and 40 healthy controls. Hormonal markers (FSH, LH, T, PRL, Ca2+, and Vitamin D3) were systematically assessed, along with Apa1 gene polymorphisms in whole blood genomic DNA using PCR-RFLP. PCOS patients showed significantly elevated LH, LH/FSH, T, and PRL levels (p < 0.01) and lower Vitamin D and calcium levels (p < 0.05) compared to controls. The scrutiny of VDR gene Apa1 polymorphism uncovered a notable prevalence of "Aa" and "aa" genotypes among PCOS patients, constituting 65.00% and 25.00%, respectively, in contrast to the control group's 17.50% and 0.00% in controls. The "aa" allele, more frequent in PCOS, emerged as a potential risk factor for the condition. This study establishes a strong association between VDR gene (Apa1) polymorphism and PCOS, highlighting the significance of the "aa" allele. It emphasizes the homozygous variant genotype "aa" as a substantial risk factor for PCOS, providing insights into its genetic basis. http://ijoir.gov.iq/ijoir/index.php/jou/article/view/418Polycystic ovary syndrome (PCOS)(VDR) geneAap1 gene |
| spellingShingle | Safa F. Ali Shiva Khezri Ilham A. Khalaf Dalia J. Mahmood Genetic Polymorphisms of the Vitamin D Receptor ApaI Gene and Physiological Parameters Diversity of Polycystic Ovary Syndrome in Iraqi Women Iraqi Journal of Industrial Research Polycystic ovary syndrome (PCOS) (VDR) gene Aap1 gene |
| title | Genetic Polymorphisms of the Vitamin D Receptor ApaI Gene and Physiological Parameters Diversity of Polycystic Ovary Syndrome in Iraqi Women |
| title_full | Genetic Polymorphisms of the Vitamin D Receptor ApaI Gene and Physiological Parameters Diversity of Polycystic Ovary Syndrome in Iraqi Women |
| title_fullStr | Genetic Polymorphisms of the Vitamin D Receptor ApaI Gene and Physiological Parameters Diversity of Polycystic Ovary Syndrome in Iraqi Women |
| title_full_unstemmed | Genetic Polymorphisms of the Vitamin D Receptor ApaI Gene and Physiological Parameters Diversity of Polycystic Ovary Syndrome in Iraqi Women |
| title_short | Genetic Polymorphisms of the Vitamin D Receptor ApaI Gene and Physiological Parameters Diversity of Polycystic Ovary Syndrome in Iraqi Women |
| title_sort | genetic polymorphisms of the vitamin d receptor apai gene and physiological parameters diversity of polycystic ovary syndrome in iraqi women |
| topic | Polycystic ovary syndrome (PCOS) (VDR) gene Aap1 gene |
| url | http://ijoir.gov.iq/ijoir/index.php/jou/article/view/418 |
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