In vitro technology and ADMET research in traditional Chinese medicine
Traditional Chinese medicine (TCM) faces many challenges in the study of absorption, distribution, metabolism, excretion and toxicity (ADME/T) because of its complexity and diversity. In vitro models, which can effectively simulate the in vivo environment and provide a platform for the analysis of t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1605330/full |
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| author | Jinhao Xue Shiwen Gao Zhibo You Shuo Xu Jiang Zhou Hai Jiang Liu Yang |
| author_facet | Jinhao Xue Shiwen Gao Zhibo You Shuo Xu Jiang Zhou Hai Jiang Liu Yang |
| author_sort | Jinhao Xue |
| collection | DOAJ |
| description | Traditional Chinese medicine (TCM) faces many challenges in the study of absorption, distribution, metabolism, excretion and toxicity (ADME/T) because of its complexity and diversity. In vitro models, which can effectively simulate the in vivo environment and provide a platform for the analysis of the efficacy and toxicity mechanism of TCMs, play important roles in the study of TCM compounds. This paper evaluates the advantages and limitations of in vitro models (including cell models, noncell traditional models, OoC and organoid technology) from the perspective of ADMET. We emphasize the innovative application of these models in analysing the absorption kinetics, brain targeting, complex metabolic pathways, excretion characteristics and potential toxicity of TCM components. This review emphasizes the advantages of in vitro methods in meeting the challenges of TCM multicomponent analysis, including the ability to study component interactions and screen potential drug candidates. In addition, we carried out a special in-depth analysis of OoC and organoid technology and systematically explored their unique advantages in the field of traditional Chinese medicine. Moreover, combined with bibliometric analysis, the literature on the Chinese medicine ADMET published in vitro in recent years was statistically summarized, and the hot spots and trends of TCM in this research were analysed. |
| format | Article |
| id | doaj-art-b8bc47abc3c84ee3b2fe8cc33b56b4dc |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b8bc47abc3c84ee3b2fe8cc33b56b4dc2025-08-20T03:28:14ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.16053301605330In vitro technology and ADMET research in traditional Chinese medicineJinhao XueShiwen GaoZhibo YouShuo XuJiang ZhouHai JiangLiu YangTraditional Chinese medicine (TCM) faces many challenges in the study of absorption, distribution, metabolism, excretion and toxicity (ADME/T) because of its complexity and diversity. In vitro models, which can effectively simulate the in vivo environment and provide a platform for the analysis of the efficacy and toxicity mechanism of TCMs, play important roles in the study of TCM compounds. This paper evaluates the advantages and limitations of in vitro models (including cell models, noncell traditional models, OoC and organoid technology) from the perspective of ADMET. We emphasize the innovative application of these models in analysing the absorption kinetics, brain targeting, complex metabolic pathways, excretion characteristics and potential toxicity of TCM components. This review emphasizes the advantages of in vitro methods in meeting the challenges of TCM multicomponent analysis, including the ability to study component interactions and screen potential drug candidates. In addition, we carried out a special in-depth analysis of OoC and organoid technology and systematically explored their unique advantages in the field of traditional Chinese medicine. Moreover, combined with bibliometric analysis, the literature on the Chinese medicine ADMET published in vitro in recent years was statistically summarized, and the hot spots and trends of TCM in this research were analysed.https://www.frontiersin.org/articles/10.3389/fphar.2025.1605330/fulltraditional Chinese medicineADMETin vitro modelOrgan-on-chiporganoids |
| spellingShingle | Jinhao Xue Shiwen Gao Zhibo You Shuo Xu Jiang Zhou Hai Jiang Liu Yang In vitro technology and ADMET research in traditional Chinese medicine Frontiers in Pharmacology traditional Chinese medicine ADMET in vitro model Organ-on-chip organoids |
| title | In vitro technology and ADMET research in traditional Chinese medicine |
| title_full | In vitro technology and ADMET research in traditional Chinese medicine |
| title_fullStr | In vitro technology and ADMET research in traditional Chinese medicine |
| title_full_unstemmed | In vitro technology and ADMET research in traditional Chinese medicine |
| title_short | In vitro technology and ADMET research in traditional Chinese medicine |
| title_sort | in vitro technology and admet research in traditional chinese medicine |
| topic | traditional Chinese medicine ADMET in vitro model Organ-on-chip organoids |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1605330/full |
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