Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation

Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation

Abstract Primary lateral sclerosis (PLS) is a motor neuron disease (MND) which mainly affects upper motor neurons. Within the MND spectrum, PLS is much more slowly progressive than amyotrophic laterals sclerosis (ALS). `Classical` ALS is characterized by catabolism and abnormal energy metabolism pre...

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Bibliographic Details
Main Authors: Jan Kassubek, Francesco Roselli, Simon Witzel, Johannes Dorst, Albert C. Ludolph, Volker Rasche, Ina Vernikouskaya, Hans-Peter Müller
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Hypothalamus
Neuronal Networks
Metabolism
Magnetic Resonance Imaging
Volumetry
Amyotrophic Lateral Sclerosis
Online Access:https://doi.org/10.1038/s41598-025-85786-6
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