Association between parental exposure to metal mixture and preterm birth: A prospective birth cohort study
Accumulating evidence suggests that maternal prenatal exposure to metals is associated with preterm birth. However, the relationship between paternal metals exposure and preterm birth remains unclear. In current study, we assessed the association of paternal exposure, maternal exposure and parental...
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Elsevier
2025-07-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325007110 |
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| author | Bo Yang Yiyuan Chen Haowen Zhang Yuxin Liu Cong Liu Hong Lv Tao Jiang Rui Qin Shiyao Tao Xin Xu Yuanyan Dou Kang Ke Tianyu Sun Yue Jiang Bo Xu Kun Zhou Jiaping Chen Guangfu Jin Hongxia Ma Hongbing Shen Yuan Lin Jiangbo Du Zhibin Hu |
| author_facet | Bo Yang Yiyuan Chen Haowen Zhang Yuxin Liu Cong Liu Hong Lv Tao Jiang Rui Qin Shiyao Tao Xin Xu Yuanyan Dou Kang Ke Tianyu Sun Yue Jiang Bo Xu Kun Zhou Jiaping Chen Guangfu Jin Hongxia Ma Hongbing Shen Yuan Lin Jiangbo Du Zhibin Hu |
| author_sort | Bo Yang |
| collection | DOAJ |
| description | Accumulating evidence suggests that maternal prenatal exposure to metals is associated with preterm birth. However, the relationship between paternal metals exposure and preterm birth remains unclear. In current study, we assessed the association of paternal exposure, maternal exposure and parental co-exposure to metals with the risk of preterm birth, using data from the Jiangsu Birth Cohort (JBC) study. Urine samples collected from 1680 couples during the first trimester were measured for 25 metals concentrations. In the multivariable logistic regression models, paternal and maternal urinary antimony (Sb) concentrations were associated with 45 % (paternal: Odds Ratio (OR), 1.45; 95 % Confidence Interval (95 %CI), 1.01–2.09) and 43 % (maternal: OR, 1.43; 95 % CI, 1.01–2.03) higher risk of preterm birth per ln-unit increase, respectively. Also, maternal urinary cobalt (Co) concentrations (OR, 1.45; 95 % CI, 1.02–2.06) and copper (Cu) concentrations (OR, 2.16; 95 % CI, 1.15–4.03) were significantly associated with an increased risk of preterm birth. In addition, maternal exposure to Cu and paternal exposure to Sb demonstrated a significant dose-response relationship, with trend test P-values of 0.037 and 0.015, respectively. These findings suggested that higher concentrations of Cu and Sb are associated with an increased risk of preterm birth. The Bayesian Kernel Machine Regression (BKMR) models revealed a positive joint effect on preterm birth that intensified across increasing quantiles of parental mixture concentrations. Our findings emphasize that metals influence the onset of preterm birth through both maternal and paternal exposure. These results lay a theoretical foundation for developing risk assessment models based on parental exposure characteristics, offering deeper insights into the etiology of preterm birth. Furthermore, they provide essential scientific evidence to support its prevention and control strategies. |
| format | Article |
| id | doaj-art-b8b45995b01c4311b40cff2abf0b967a |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-b8b45995b01c4311b40cff2abf0b967a2025-08-20T03:07:50ZengElsevierEcotoxicology and Environmental Safety0147-65132025-07-0129911837510.1016/j.ecoenv.2025.118375Association between parental exposure to metal mixture and preterm birth: A prospective birth cohort studyBo Yang0Yiyuan Chen1Haowen Zhang2Yuxin Liu3Cong Liu4Hong Lv5Tao Jiang6Rui Qin7Shiyao Tao8Xin Xu9Yuanyan Dou10Kang Ke11Tianyu Sun12Yue Jiang13Bo Xu14Kun Zhou15Jiaping Chen16Guangfu Jin17Hongxia Ma18Hongbing Shen19Yuan Lin20Jiangbo Du21Zhibin Hu22Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Correspondence to: Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China; Department of Obstetrics and Gynecology, Taizhou People's Hospital, Affiliated to Nanjing Medical University, Taizhou, Jiangsu, China; Corresponding authors at: State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China; Corresponding authors at: State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, ChinaAccumulating evidence suggests that maternal prenatal exposure to metals is associated with preterm birth. However, the relationship between paternal metals exposure and preterm birth remains unclear. In current study, we assessed the association of paternal exposure, maternal exposure and parental co-exposure to metals with the risk of preterm birth, using data from the Jiangsu Birth Cohort (JBC) study. Urine samples collected from 1680 couples during the first trimester were measured for 25 metals concentrations. In the multivariable logistic regression models, paternal and maternal urinary antimony (Sb) concentrations were associated with 45 % (paternal: Odds Ratio (OR), 1.45; 95 % Confidence Interval (95 %CI), 1.01–2.09) and 43 % (maternal: OR, 1.43; 95 % CI, 1.01–2.03) higher risk of preterm birth per ln-unit increase, respectively. Also, maternal urinary cobalt (Co) concentrations (OR, 1.45; 95 % CI, 1.02–2.06) and copper (Cu) concentrations (OR, 2.16; 95 % CI, 1.15–4.03) were significantly associated with an increased risk of preterm birth. In addition, maternal exposure to Cu and paternal exposure to Sb demonstrated a significant dose-response relationship, with trend test P-values of 0.037 and 0.015, respectively. These findings suggested that higher concentrations of Cu and Sb are associated with an increased risk of preterm birth. The Bayesian Kernel Machine Regression (BKMR) models revealed a positive joint effect on preterm birth that intensified across increasing quantiles of parental mixture concentrations. Our findings emphasize that metals influence the onset of preterm birth through both maternal and paternal exposure. These results lay a theoretical foundation for developing risk assessment models based on parental exposure characteristics, offering deeper insights into the etiology of preterm birth. Furthermore, they provide essential scientific evidence to support its prevention and control strategies.http://www.sciencedirect.com/science/article/pii/S0147651325007110Birth cohortMetalParental exposurePreterm birth |
| spellingShingle | Bo Yang Yiyuan Chen Haowen Zhang Yuxin Liu Cong Liu Hong Lv Tao Jiang Rui Qin Shiyao Tao Xin Xu Yuanyan Dou Kang Ke Tianyu Sun Yue Jiang Bo Xu Kun Zhou Jiaping Chen Guangfu Jin Hongxia Ma Hongbing Shen Yuan Lin Jiangbo Du Zhibin Hu Association between parental exposure to metal mixture and preterm birth: A prospective birth cohort study Ecotoxicology and Environmental Safety Birth cohort Metal Parental exposure Preterm birth |
| title | Association between parental exposure to metal mixture and preterm birth: A prospective birth cohort study |
| title_full | Association between parental exposure to metal mixture and preterm birth: A prospective birth cohort study |
| title_fullStr | Association between parental exposure to metal mixture and preterm birth: A prospective birth cohort study |
| title_full_unstemmed | Association between parental exposure to metal mixture and preterm birth: A prospective birth cohort study |
| title_short | Association between parental exposure to metal mixture and preterm birth: A prospective birth cohort study |
| title_sort | association between parental exposure to metal mixture and preterm birth a prospective birth cohort study |
| topic | Birth cohort Metal Parental exposure Preterm birth |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325007110 |
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