Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl Concentration
Background: Protein carbonyl levels are the most frequently used biomarker of protein oxidation in several human diseases, including cancer. Breast cancer, a worldwide disease with increasing incidence, develops from ductal/lobular epithelium from which nipple aspirate fluid can be collected and ana...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0483 |
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| _version_ | 1832552877676036096 |
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| author | Ferdinando Mannello Gaetana A. Tonti Virginia Medda |
| author_facet | Ferdinando Mannello Gaetana A. Tonti Virginia Medda |
| author_sort | Ferdinando Mannello |
| collection | DOAJ |
| description | Background: Protein carbonyl levels are the most frequently used biomarker of protein oxidation in several human diseases, including cancer. Breast cancer, a worldwide disease with increasing incidence, develops from ductal/lobular epithelium from which nipple aspirate fluid can be collected and analysed to assess tissue metabolic activity. Our aims were to perform an exploratory investigation on the protein carbonyl accumulation in breast secretions from healthy and cancer patients and its correlation with lipid peroxidation markers. |
| format | Article |
| id | doaj-art-b8b338a343e8421c93db3180f0a18cc7 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-b8b338a343e8421c93db3180f0a18cc72025-02-03T05:57:36ZengWileyCellular Oncology1570-58701875-86062009-01-0131538339210.3233/CLO-2009-0483Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl ConcentrationFerdinando Mannello0Gaetana A. Tonti1Virginia Medda2Department of Biomolecular Sciences, Section of Clinical Biochemistry, University of Urbino, Urbino, ItalyDepartment of Biomolecular Sciences, Section of Clinical Biochemistry, University of Urbino, Urbino, ItalyDepartment of Biomolecular Sciences, Section of Clinical Biochemistry, University of Urbino, Urbino, ItalyBackground: Protein carbonyl levels are the most frequently used biomarker of protein oxidation in several human diseases, including cancer. Breast cancer, a worldwide disease with increasing incidence, develops from ductal/lobular epithelium from which nipple aspirate fluid can be collected and analysed to assess tissue metabolic activity. Our aims were to perform an exploratory investigation on the protein carbonyl accumulation in breast secretions from healthy and cancer patients and its correlation with lipid peroxidation markers.http://dx.doi.org/10.3233/CLO-2009-0483 |
| spellingShingle | Ferdinando Mannello Gaetana A. Tonti Virginia Medda Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl Concentration Cellular Oncology |
| title | Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl Concentration |
| title_full | Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl Concentration |
| title_fullStr | Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl Concentration |
| title_full_unstemmed | Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl Concentration |
| title_short | Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl Concentration |
| title_sort | protein oxidation in breast microenvironment nipple aspirate fluid collected from breast cancer women contains increased protein carbonyl concentration |
| url | http://dx.doi.org/10.3233/CLO-2009-0483 |
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