RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress
RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularl...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/287345 |
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| _version_ | 1849686038368223232 |
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| author | Er-Chieh Cho Mei-Ling Kuo Jia-hui Cheng Yu-Chi Cheng Yi-Chen Hsieh Yun-Ru Liu Rong-Hong Hsieh Yun Yen |
| author_facet | Er-Chieh Cho Mei-Ling Kuo Jia-hui Cheng Yu-Chi Cheng Yi-Chen Hsieh Yun-Ru Liu Rong-Hong Hsieh Yun Yen |
| author_sort | Er-Chieh Cho |
| collection | DOAJ |
| description | RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularly under oxidative stress, remains largely unknown. In this study, we investigated the role of RRM2B underoxidative stress-induced DNA damage and further examined the regulation of mitochondrial and inflammatory genes by RRM2B. Our study is the first to report the critical role of RRM2B in mitochondrial homeostasis and the inflammation signaling pathway in a p53-independent manner. Furthermore, our study provides novel insights into the role of the RR in inflammatory diseases. |
| format | Article |
| id | doaj-art-b8b230ac0f0d41e9aeb87360b36c66b2 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b8b230ac0f0d41e9aeb87360b36c66b22025-08-20T03:22:50ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/287345287345RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative StressEr-Chieh Cho0Mei-Ling Kuo1Jia-hui Cheng2Yu-Chi Cheng3Yi-Chen Hsieh4Yun-Ru Liu5Rong-Hong Hsieh6Yun Yen7Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, TaiwanDepartment of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USADepartment of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, TaiwanSchool of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, Taipei 110, TaiwanPh.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110, TaiwanJoint Biobank, Office of Human Research, Taipei Medical University, Taipei 110, TaiwanSchool of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, TaiwanRRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularly under oxidative stress, remains largely unknown. In this study, we investigated the role of RRM2B underoxidative stress-induced DNA damage and further examined the regulation of mitochondrial and inflammatory genes by RRM2B. Our study is the first to report the critical role of RRM2B in mitochondrial homeostasis and the inflammation signaling pathway in a p53-independent manner. Furthermore, our study provides novel insights into the role of the RR in inflammatory diseases.http://dx.doi.org/10.1155/2015/287345 |
| spellingShingle | Er-Chieh Cho Mei-Ling Kuo Jia-hui Cheng Yu-Chi Cheng Yi-Chen Hsieh Yun-Ru Liu Rong-Hong Hsieh Yun Yen RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress Mediators of Inflammation |
| title | RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress |
| title_full | RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress |
| title_fullStr | RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress |
| title_full_unstemmed | RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress |
| title_short | RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress |
| title_sort | rrm2b mediated regulation of mitochondrial activity and inflammation under oxidative stress |
| url | http://dx.doi.org/10.1155/2015/287345 |
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