Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review
Periodontitis (PD), is a chronic inflammatory disease of the periodontal system, which includes gingiva, periodontal ligament, alveolar bone, and tooth cement. It is becoming increasingly prevalent globally, and its implications for oral health are profound. The Nrf2 signaling pathway is crucial in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/13/7/314 |
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| author | Sarmistha Saha Nadezhda Sachivkina Ekaterina Lenchenko Olga Pilshchikova Alexandr Muraev |
| author_facet | Sarmistha Saha Nadezhda Sachivkina Ekaterina Lenchenko Olga Pilshchikova Alexandr Muraev |
| author_sort | Sarmistha Saha |
| collection | DOAJ |
| description | Periodontitis (PD), is a chronic inflammatory disease of the periodontal system, which includes gingiva, periodontal ligament, alveolar bone, and tooth cement. It is becoming increasingly prevalent globally, and its implications for oral health are profound. The Nrf2 signaling pathway is crucial in managing the relationship between inflammation and oxidative stress, making it vital for understanding this disease. Nrf2 interacts with key redox-sensitive inflammatory pathways, playing a vital role in the development of periodontitis. Acknowledging these dynamics underscores the importance of proactively addressing the complex aspects of periodontal disease. This review emphasizes its intricate interactions with redox-sensitive transcription factors vital for sustaining the self-perpetuating inflammatory processes underlying the disease. Additionally, it explores promising therapeutic strategies aimed at Nrf2 activation and encourages more effective management of PD. |
| format | Article |
| id | doaj-art-b8b20c4458eb47dbab2851b7ec35e51a |
| institution | Kabale University |
| issn | 2304-6767 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj-art-b8b20c4458eb47dbab2851b7ec35e51a2025-08-20T03:58:27ZengMDPI AGDentistry Journal2304-67672025-07-0113731410.3390/dj13070314Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative ReviewSarmistha Saha0Nadezhda Sachivkina1Ekaterina Lenchenko2Olga Pilshchikova3Alexandr Muraev4Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura 281406, Uttar Pradesh, IndiaDepartment of Microbiology V.S. Kiktenko, Institute of Medicine, Peoples’ Friendship University of Russia Named After Patrice Lumumba (RUDN University), 117198 Moscow, RussiaDepartment of Veterinary Medicine, Russian Biotechnological University (BIOTECH University), 125080 Moscow, RussiaDepartment of Therapeutic Dentistry, Institute of Medicine, Peoples Friendship University of Russia (RUDN University), 117198 Moscow, RussiaDepartment of Oral and Maxillofacial Surgery, Institute of Medicine, Peoples’ Friendship University of Russia Named After Patrice Lumumba (RUDN University), 117198 Moscow, RussiaPeriodontitis (PD), is a chronic inflammatory disease of the periodontal system, which includes gingiva, periodontal ligament, alveolar bone, and tooth cement. It is becoming increasingly prevalent globally, and its implications for oral health are profound. The Nrf2 signaling pathway is crucial in managing the relationship between inflammation and oxidative stress, making it vital for understanding this disease. Nrf2 interacts with key redox-sensitive inflammatory pathways, playing a vital role in the development of periodontitis. Acknowledging these dynamics underscores the importance of proactively addressing the complex aspects of periodontal disease. This review emphasizes its intricate interactions with redox-sensitive transcription factors vital for sustaining the self-perpetuating inflammatory processes underlying the disease. Additionally, it explores promising therapeutic strategies aimed at Nrf2 activation and encourages more effective management of PD.https://www.mdpi.com/2304-6767/13/7/314periodontitisNrf2oxidative stresspharmacotherapy |
| spellingShingle | Sarmistha Saha Nadezhda Sachivkina Ekaterina Lenchenko Olga Pilshchikova Alexandr Muraev Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review Dentistry Journal periodontitis Nrf2 oxidative stress pharmacotherapy |
| title | Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review |
| title_full | Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review |
| title_fullStr | Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review |
| title_full_unstemmed | Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review |
| title_short | Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review |
| title_sort | activation of the nrf2 signaling pathway as a therapeutic strategy against periodontal disease a narrative review |
| topic | periodontitis Nrf2 oxidative stress pharmacotherapy |
| url | https://www.mdpi.com/2304-6767/13/7/314 |
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