Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis

Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis

Abstract Sodium aescinate (SA), a natural plant extract with various bioactivities, is widely used to treat oedema and inflammation in clinics. However, adverse events, including liver injury, kidney injury, and phlebitis, have been reported in patients with SA in recent years. In this study, we use...

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Bibliographic Details
Main Authors: Chen Xi, Jie Zhou, Xin Zheng, Xiaoyi Fu, Minjuan Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Sodium aescinate
ATF4
GSH
Ferroptosis
Hepatotoxicity
Online Access:https://doi.org/10.1038/s41598-024-79723-2
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