Quantitative MRI Assessment of Supraspinatus Tendon Remodeling Following a Single Platelet-Rich Plasma Injection Using <i>T</i><sub>2</sub> Mapping and Relaxation Time Profiling
<b>Background:</b> Quantitative magnetic resonance imaging (MRI) techniques such as <i>T</i><sub>2</sub> mapping may detect early tendon changes following biologic therapies. This study aimed to assess the structural remodeling of the supraspinatus tendon using me...
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MDPI AG
2025-04-01
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| author | Karlo Pintarić Andrej Vovk Vladka Salapura Žiga Snoj Jernej Vidmar |
| author_facet | Karlo Pintarić Andrej Vovk Vladka Salapura Žiga Snoj Jernej Vidmar |
| author_sort | Karlo Pintarić |
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| description | <b>Background:</b> Quantitative magnetic resonance imaging (MRI) techniques such as <i>T</i><sub>2</sub> mapping may detect early tendon changes following biologic therapies. This study aimed to assess the structural remodeling of the supraspinatus tendon using mean <i>T</i><sub>2</sub> values and <i>T</i><sub>2</sub> distribution profiles after an ultrasound (US)-guided single platelet-rich plasma (PRP) injection. <b>Methods:</b> Twenty-six patients with symptomatic supraspinatus tendinopathy were divided into tendinosis (<i>n</i> = 9) and partial tear (<i>n</i> = 13) groups. <i>T</i><sub>2</sub> mapping and clinical evaluations (shoulder pain and disability index questionnaire (SPADI), Constant-Murley score) were conducted at baseline and 6 months post-PRP. Mean <i>T</i><sub>2</sub> values were measured in three tendon segments (lateral, middle, and medial), and <i>T</i><sub>2</sub> profiles were compared to asymptomatic controls. <b>Results:</b> Clinical outcomes showed significant improvement in both the tendinosis and partial tear groups at the 6-month follow-up. Although no significant changes were observed in the mean <i>T</i><sub>2</sub> relaxation times across tendon segments following PRP treatment, <i>T</i><sub>2</sub> distribution profiling revealed statistically significant alterations in both groups. In the tendinosis group, post-treatment <i>T</i><sub>2</sub> profiles approached those of the asymptomatic controls, suggesting structural remodeling consistent with tendon healing. <b>Conclusions:</b> <i>T</i><sub>2</sub> mapping is an effective tool for detecting tendon remodeling following PRP therapy. Structural improvements indicative of tissue healing were observed in cases of tendinosis, but not in partial tendon tears. These findings support the use of <i>T</i><sub>2</sub> mapping—particularly the <i>T</i><sub>2</sub> distribution profiling—as a quantitative biomarker for assessing treatment response to PRP. |
| format | Article |
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| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-b8a84bd865964716b919c0e5ca9d0b072025-08-20T02:28:28ZengMDPI AGDiagnostics2075-44182025-04-01158104910.3390/diagnostics15081049Quantitative MRI Assessment of Supraspinatus Tendon Remodeling Following a Single Platelet-Rich Plasma Injection Using <i>T</i><sub>2</sub> Mapping and Relaxation Time ProfilingKarlo Pintarić0Andrej Vovk1Vladka Salapura2Žiga Snoj3Jernej Vidmar4Institute of Radiology, University Medical Centre Ljubljana, 1000 Ljubljana, SloveniaCentre of Clinical Physiology, Medical Faculty, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Radiology, University Medical Centre Ljubljana, 1000 Ljubljana, SloveniaInstitute of Radiology, University Medical Centre Ljubljana, 1000 Ljubljana, SloveniaInstitute of Radiology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia<b>Background:</b> Quantitative magnetic resonance imaging (MRI) techniques such as <i>T</i><sub>2</sub> mapping may detect early tendon changes following biologic therapies. This study aimed to assess the structural remodeling of the supraspinatus tendon using mean <i>T</i><sub>2</sub> values and <i>T</i><sub>2</sub> distribution profiles after an ultrasound (US)-guided single platelet-rich plasma (PRP) injection. <b>Methods:</b> Twenty-six patients with symptomatic supraspinatus tendinopathy were divided into tendinosis (<i>n</i> = 9) and partial tear (<i>n</i> = 13) groups. <i>T</i><sub>2</sub> mapping and clinical evaluations (shoulder pain and disability index questionnaire (SPADI), Constant-Murley score) were conducted at baseline and 6 months post-PRP. Mean <i>T</i><sub>2</sub> values were measured in three tendon segments (lateral, middle, and medial), and <i>T</i><sub>2</sub> profiles were compared to asymptomatic controls. <b>Results:</b> Clinical outcomes showed significant improvement in both the tendinosis and partial tear groups at the 6-month follow-up. Although no significant changes were observed in the mean <i>T</i><sub>2</sub> relaxation times across tendon segments following PRP treatment, <i>T</i><sub>2</sub> distribution profiling revealed statistically significant alterations in both groups. In the tendinosis group, post-treatment <i>T</i><sub>2</sub> profiles approached those of the asymptomatic controls, suggesting structural remodeling consistent with tendon healing. <b>Conclusions:</b> <i>T</i><sub>2</sub> mapping is an effective tool for detecting tendon remodeling following PRP therapy. Structural improvements indicative of tissue healing were observed in cases of tendinosis, but not in partial tendon tears. These findings support the use of <i>T</i><sub>2</sub> mapping—particularly the <i>T</i><sub>2</sub> distribution profiling—as a quantitative biomarker for assessing treatment response to PRP.https://www.mdpi.com/2075-4418/15/8/1049<i>T</i><sub>2</sub> mappingPRPsupraspinatus tendontendinosismagnetic resonance imaging |
| spellingShingle | Karlo Pintarić Andrej Vovk Vladka Salapura Žiga Snoj Jernej Vidmar Quantitative MRI Assessment of Supraspinatus Tendon Remodeling Following a Single Platelet-Rich Plasma Injection Using <i>T</i><sub>2</sub> Mapping and Relaxation Time Profiling Diagnostics <i>T</i><sub>2</sub> mapping PRP supraspinatus tendon tendinosis magnetic resonance imaging |
| title | Quantitative MRI Assessment of Supraspinatus Tendon Remodeling Following a Single Platelet-Rich Plasma Injection Using <i>T</i><sub>2</sub> Mapping and Relaxation Time Profiling |
| title_full | Quantitative MRI Assessment of Supraspinatus Tendon Remodeling Following a Single Platelet-Rich Plasma Injection Using <i>T</i><sub>2</sub> Mapping and Relaxation Time Profiling |
| title_fullStr | Quantitative MRI Assessment of Supraspinatus Tendon Remodeling Following a Single Platelet-Rich Plasma Injection Using <i>T</i><sub>2</sub> Mapping and Relaxation Time Profiling |
| title_full_unstemmed | Quantitative MRI Assessment of Supraspinatus Tendon Remodeling Following a Single Platelet-Rich Plasma Injection Using <i>T</i><sub>2</sub> Mapping and Relaxation Time Profiling |
| title_short | Quantitative MRI Assessment of Supraspinatus Tendon Remodeling Following a Single Platelet-Rich Plasma Injection Using <i>T</i><sub>2</sub> Mapping and Relaxation Time Profiling |
| title_sort | quantitative mri assessment of supraspinatus tendon remodeling following a single platelet rich plasma injection using i t i sub 2 sub mapping and relaxation time profiling |
| topic | <i>T</i><sub>2</sub> mapping PRP supraspinatus tendon tendinosis magnetic resonance imaging |
| url | https://www.mdpi.com/2075-4418/15/8/1049 |
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