Syntactic Comprehension in Patients with Amyotrophic Lateral Sclerosis
Recent neuropsychological studies of patients with amyotrophic lateral sclerosis (ALS) have demonstrated that some patients have aphasic symptoms, including impaired syntactic comprehension. However, it is not known if syntactic comprehension disorder is related to executive and visuospatial dysfunc...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2014/230578 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554110790926336 |
|---|---|
| author | Kentarou Yoshizawa Nao Yasuda Michinari Fukuda Yumi Yukimoto Mieko Ogino Wakana Hata Ikuyo Ishizaka Mari Higashikawa |
| author_facet | Kentarou Yoshizawa Nao Yasuda Michinari Fukuda Yumi Yukimoto Mieko Ogino Wakana Hata Ikuyo Ishizaka Mari Higashikawa |
| author_sort | Kentarou Yoshizawa |
| collection | DOAJ |
| description | Recent neuropsychological studies of patients with amyotrophic lateral sclerosis (ALS) have demonstrated that some patients have aphasic symptoms, including impaired syntactic comprehension. However, it is not known if syntactic comprehension disorder is related to executive and visuospatial dysfunction. In this study, we evaluated syntactic comprehension using the Syntax Test for Aphasia (STA) auditory comprehension task, frontal executive function using the Frontal Assessment Battery (FAB), visuospatial function using Raven’s Coloured Progressive Matrices (RCPM), and dementia using the Hasegawa Dementia Scale-Revised (HDS-R) in 25 patients with ALS. Of the 25 patients, 18 (72%) had syntactic comprehension disorder (STA score < IV), nine (36%) had frontal executive dysfunction (FAB score < 14), six (24%) had visuospatial dysfunction (RCPM score < 24), and none had dementia (HDS-R score < 20). Nine of the 18 patients with syntactic comprehension disorder (50%) passed the FAB and RCPM. Although sample size was small, these patients had a low STA score but normal FAB and RCPM score. All patients with bulbar onset ALS had syntactic comprehension disorder. These results indicate that it might be necessary to assess syntactic comprehension in patients with bulbar onset ALS. The implications of these findings are discussed in relation to the pathological continuum of ALS. |
| format | Article |
| id | doaj-art-b8a17dcf8a13446a9e7a66d480e65a17 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-b8a17dcf8a13446a9e7a66d480e65a172025-02-03T05:52:22ZengWileyBehavioural Neurology0953-41801875-85842014-01-01201410.1155/2014/230578230578Syntactic Comprehension in Patients with Amyotrophic Lateral SclerosisKentarou Yoshizawa0Nao Yasuda1Michinari Fukuda2Yumi Yukimoto3Mieko Ogino4Wakana Hata5Ikuyo Ishizaka6Mari Higashikawa7Department of Rehabilitation, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanDepartment of Rehabilitation, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanDepartment of Rehabilitation, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanDepartment of Rehabilitation, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanDepartment of Neurology, School of Medicine, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, JapanDepartment of Rehabilitation, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanSchool of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, JapanSchool of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, JapanRecent neuropsychological studies of patients with amyotrophic lateral sclerosis (ALS) have demonstrated that some patients have aphasic symptoms, including impaired syntactic comprehension. However, it is not known if syntactic comprehension disorder is related to executive and visuospatial dysfunction. In this study, we evaluated syntactic comprehension using the Syntax Test for Aphasia (STA) auditory comprehension task, frontal executive function using the Frontal Assessment Battery (FAB), visuospatial function using Raven’s Coloured Progressive Matrices (RCPM), and dementia using the Hasegawa Dementia Scale-Revised (HDS-R) in 25 patients with ALS. Of the 25 patients, 18 (72%) had syntactic comprehension disorder (STA score < IV), nine (36%) had frontal executive dysfunction (FAB score < 14), six (24%) had visuospatial dysfunction (RCPM score < 24), and none had dementia (HDS-R score < 20). Nine of the 18 patients with syntactic comprehension disorder (50%) passed the FAB and RCPM. Although sample size was small, these patients had a low STA score but normal FAB and RCPM score. All patients with bulbar onset ALS had syntactic comprehension disorder. These results indicate that it might be necessary to assess syntactic comprehension in patients with bulbar onset ALS. The implications of these findings are discussed in relation to the pathological continuum of ALS.http://dx.doi.org/10.1155/2014/230578 |
| spellingShingle | Kentarou Yoshizawa Nao Yasuda Michinari Fukuda Yumi Yukimoto Mieko Ogino Wakana Hata Ikuyo Ishizaka Mari Higashikawa Syntactic Comprehension in Patients with Amyotrophic Lateral Sclerosis Behavioural Neurology |
| title | Syntactic Comprehension in Patients with Amyotrophic Lateral Sclerosis |
| title_full | Syntactic Comprehension in Patients with Amyotrophic Lateral Sclerosis |
| title_fullStr | Syntactic Comprehension in Patients with Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Syntactic Comprehension in Patients with Amyotrophic Lateral Sclerosis |
| title_short | Syntactic Comprehension in Patients with Amyotrophic Lateral Sclerosis |
| title_sort | syntactic comprehension in patients with amyotrophic lateral sclerosis |
| url | http://dx.doi.org/10.1155/2014/230578 |
| work_keys_str_mv | AT kentarouyoshizawa syntacticcomprehensioninpatientswithamyotrophiclateralsclerosis AT naoyasuda syntacticcomprehensioninpatientswithamyotrophiclateralsclerosis AT michinarifukuda syntacticcomprehensioninpatientswithamyotrophiclateralsclerosis AT yumiyukimoto syntacticcomprehensioninpatientswithamyotrophiclateralsclerosis AT miekoogino syntacticcomprehensioninpatientswithamyotrophiclateralsclerosis AT wakanahata syntacticcomprehensioninpatientswithamyotrophiclateralsclerosis AT ikuyoishizaka syntacticcomprehensioninpatientswithamyotrophiclateralsclerosis AT marihigashikawa syntacticcomprehensioninpatientswithamyotrophiclateralsclerosis |