Lawsonia intracellularis T3SS effector LI0758, an Rce1 ortholog, activates MAPK and NF-κB signaling in mammalian cells

Lawsonia intracellularis T3SS effector LI0758, an Rce1 ortholog, activates MAPK and NF-κB signaling in mammalian cells

Abstract Lawsonia intracellularis, a Gram-negative obligate intracellular bacterium causing porcine proliferative enteropathy, possesses a type III secretion system (T3SS), yet only a handful of its substrates have been experimentally characterized. In this study, we identify that LI0758 can be secr...

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Bibliographic Details
Main Authors: Yuanxiu Zhong, Yiyun Duan, Fenju Lai, Jinhua Zhang, Yimin Dai
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Veterinary Research
Subjects:
L. intracellularis
type III secretion system
MAPK
NF-κB
prenylation
Rce1
Online Access:https://doi.org/10.1186/s13567-025-01461-8
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