Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2high thecal cell proliferation in androgen-induced PCOS mice

Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2high thecal cell proliferation in androgen-induced PCOS mice

BackgroundPolycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by elevated androgen levels and impaired follicular development. A hallmark of PCOS is the excessive proliferation of thecal cells (TCs), which are critical for androgen production. However, the molecular mechani...

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Main Authors: Man Luo, Xiaona Tian, Li Li, Guomei Zhang, Wenzhi Liu, Linlin Mei, Haoran Li, Xiaoyan You, Dongmei Zhang, Mengsi Zhou, Cheng Xiao, Jianping Ye, Xiaofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
polycystic ovary syndrome
spatial transcriptomic
thecal cell
androgen
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1633254/full
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