Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury
Acute kidney injury (AKI) is a common and severe clinical disorder in which endoplasmic reticulum (ER) stress plays an important regulatory role. In this review, we summarize the research progress on the relationship between ER stress and AKI. It emphasizes the importance of maintaining a balance be...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2433160 |
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| author | Li-Ran Zhu Wei Cui Hai-Peng Liu |
| author_facet | Li-Ran Zhu Wei Cui Hai-Peng Liu |
| author_sort | Li-Ran Zhu |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a common and severe clinical disorder in which endoplasmic reticulum (ER) stress plays an important regulatory role. In this review, we summarize the research progress on the relationship between ER stress and AKI. It emphasizes the importance of maintaining a balance between promoting and protecting ER stress during AKI and highlights the potential of ER stress-targeted drugs as a new therapeutic approach for AKI. The article also discusses the need for developing drugs that target ER stress effectively while avoiding adverse effects on normal cells and tissues. The review concludes that with a more comprehensive understanding of ER stress mechanisms and advancements in research techniques, more effective treatment options for AKI can be developed in the future. |
| format | Article |
| id | doaj-art-b89889d8f2a24d2e81fab1794eba7cd8 |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-b89889d8f2a24d2e81fab1794eba7cd82025-08-20T03:12:51ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2433160Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injuryLi-Ran Zhu0Wei Cui1Hai-Peng Liu2Anhui Institute of Pediatric Research, Anhui Provincial Children’s Hospital (Children’s Hospital of Fudan University Anhui Hospital; Children’s Medical Center of Anhui Medical University), Hefei, Anhui, ChinaDepartment of Scientific Research and Education, Anhui Provincial Children’s Hospital (Children’s Hospital of Fudan University Anhui Hospital; Children’s Medical Center of Anhui Medical University), Hefei, Anhui, ChinaAnhui Institute of Pediatric Research, Anhui Provincial Children’s Hospital (Children’s Hospital of Fudan University Anhui Hospital; Children’s Medical Center of Anhui Medical University), Hefei, Anhui, ChinaAcute kidney injury (AKI) is a common and severe clinical disorder in which endoplasmic reticulum (ER) stress plays an important regulatory role. In this review, we summarize the research progress on the relationship between ER stress and AKI. It emphasizes the importance of maintaining a balance between promoting and protecting ER stress during AKI and highlights the potential of ER stress-targeted drugs as a new therapeutic approach for AKI. The article also discusses the need for developing drugs that target ER stress effectively while avoiding adverse effects on normal cells and tissues. The review concludes that with a more comprehensive understanding of ER stress mechanisms and advancements in research techniques, more effective treatment options for AKI can be developed in the future.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2433160Acute kidney injuryendoplasmic reticulumsignaling pathwaytherapeutic approach |
| spellingShingle | Li-Ran Zhu Wei Cui Hai-Peng Liu Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury Renal Failure Acute kidney injury endoplasmic reticulum signaling pathway therapeutic approach |
| title | Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury |
| title_full | Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury |
| title_fullStr | Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury |
| title_full_unstemmed | Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury |
| title_short | Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury |
| title_sort | research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury |
| topic | Acute kidney injury endoplasmic reticulum signaling pathway therapeutic approach |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2433160 |
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